5V7W
Crystal structure of human PARP14 bound to 2-{[(1-methylpiperidin-4-yl)methyl]amino}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Poly [ADP-ribose] polymerase 14 | polymer | 194 | 22101.5 | 2 | UniProt (Q460N5) Pfam (PF00644) | Homo sapiens (Human) | PARP-14,ADP-ribosyltransferase diphtheria toxin-like 8,ARTD8,B aggressive lymphoma protein 2 |
| 2 | C, D (A, B) | 2-{[(1-methylpiperidin-4-yl)methyl]amino}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | non-polymer | 332.5 | 2 | Chemie (91J) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 132 | Chemie (HOH) |
Sequence modifications
A, B: 1610 - 1801 (UniProt: Q460N5)
| PDB | External Database | Details |
|---|---|---|
| Gly 1608 | - | expression tag |
| Gly 1609 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 44203.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 664.9 | |
| All* | Total formula weight | 44867.9 |
