5V7Q
Cryo-EM structure of the large ribosomal subunit from Mycobacterium tuberculosis bound with a potent linezolid analog
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (0) | 50S ribosomal protein L32 | polymer | 57 | 6525.8 | 1 | UniProt (A0A045IMI5) Pfam (PF01783) UniProt (by SIFTS) (P9WH99) | Mycobacterium tuberculosis | |
| 2 | B (1) | 50S ribosomal protein L33 | polymer | 55 | 6512.6 | 1 | UniProt (A0A045HU86) Pfam (PF00471) UniProt (by SIFTS) (P9WH95) | Mycobacterium tuberculosis | |
| 3 | C (2) | 50S ribosomal protein L34 | polymer | 47 | 5643.7 | 1 | UniProt (A0A1L6JUG3) Pfam (PF00468) UniProt (by SIFTS) (P9WH93) | Mycobacterium tuberculosis | |
| 4 | D (3) | 50S ribosomal protein L35 | polymer | 64 | 7241.4 | 1 | UniProt (A0A045KKY9) Pfam (PF01632) UniProt (by SIFTS) (P9WH91) | Mycobacterium tuberculosis | |
| 5 | E (4) | 50S ribosomal protein L36 | polymer | 37 | 4323.2 | 1 | UniProt (A0A1L6JSF4) Pfam (PF00444) UniProt (by SIFTS) (P9WH89) | Mycobacterium tuberculosis | |
| 6 | F (6) | 50S ribosomal protein L31 | polymer | 80 | 8770.1 | 1 | UniProt (A0A045HLX7) Pfam (PF01197) UniProt (by SIFTS) (P9WHA1) | Mycobacterium tuberculosis | |
| 7 | G (A) | 23S rRNA | polymer | 3138 | 1017792.6 | 1 | GenBank (984989958) | Mycobacterium tuberculosis | |
| 8 | H (B) | 5S ribosomal RNA | polymer | 115 | 37097.2 | 1 | GenBank (1092945381) | Mycobacterium tuberculosis | |
| 9 | I (C) | 50S ribosomal protein L2 | polymer | 280 | 30644.0 | 1 | UniProt (A0A045H5T7) Pfam (PF00181) Pfam (PF03947) UniProt (by SIFTS) (P9WHA5) | Mycobacterium tuberculosis | |
| 10 | J (D) | 50S ribosomal protein L3 | polymer | 217 | 23127.5 | 1 | UniProt (A0A045HU18) Pfam (PF00297) UniProt (by SIFTS) (P9WH87) | Mycobacterium tuberculosis | |
| 11 | K (E) | 50S ribosomal protein L4 | polymer | 223 | 23779.9 | 1 | UniProt (A0A045J9H1) Pfam (PF00573) UniProt (by SIFTS) (P9WH85) | Mycobacterium tuberculosis | |
| 12 | L (F) | 50S ribosomal protein L5 | polymer | 187 | 21052.3 | 1 | UniProt (A0A045HUU0) Pfam (PF00281) Pfam (PF00673) UniProt (by SIFTS) (P9WH83) | Mycobacterium tuberculosis | |
| 13 | M (G) | 50S ribosomal protein L6 | polymer | 179 | 19408.4 | 1 | UniProt (A0A045JJU1) Pfam (PF00347) UniProt (by SIFTS) (P9WH81) | Mycobacterium tuberculosis | |
| 14 | N (H) | 50S ribosomal protein L9 | polymer | 152 | 16196.7 | 1 | UniProt (A0A045JW48) Pfam (PF01281) Pfam (PF03948) UniProt (by SIFTS) (P9WH79) | Mycobacterium tuberculosis | |
| 15 | O (J) | 50S ribosomal protein L13 | polymer | 147 | 16333.9 | 1 | UniProt (A0A0T9D5H2) Pfam (PF00572) UniProt (by SIFTS) (P9WHE1) | Mycobacterium tuberculosis | |
| 16 | P (K) | 50S ribosomal protein L14 | polymer | 122 | 13419.6 | 1 | UniProt (A0A0U0S3A8) Pfam (PF00238) UniProt (by SIFTS) (P9WHD9) | Mycobacterium tuberculosis | |
| 17 | Q (L) | 50S ribosomal protein L15 | polymer | 146 | 15534.1 | 1 | UniProt (A0A0T7M0A0) Pfam (PF00828) UniProt (by SIFTS) (P9WHD7) | Mycobacterium tuberculosis | |
| 18 | R (M) | 50S ribosomal protein L16 | polymer | 138 | 15724.3 | 1 | UniProt (A0A045IWV9) Pfam (PF00252) UniProt (by SIFTS) (P9WHD5) | Mycobacterium tuberculosis | |
| 19 | S (N) | 50S ribosomal protein L17 | polymer | 180 | 19512.3 | 1 | UniProt (A0A045IVA2) Pfam (PF01196) UniProt (by SIFTS) (P9WHD3) | Mycobacterium tuberculosis | |
| 20 | T (O) | 50S ribosomal protein L18 | polymer | 122 | 13211.1 | 1 | UniProt (A0A045JK28) Pfam (PF00861) UniProt (by SIFTS) (P9WHD1) | Mycobacterium tuberculosis | |
| 21 | U (P) | 50S ribosomal protein L19 | polymer | 113 | 13041.1 | 1 | UniProt (A0A045IDD2) Pfam (PF01245) UniProt (by SIFTS) (P9WHC9) | Mycobacterium tuberculosis | |
| 22 | V (Q) | 50S ribosomal protein L20 | polymer | 129 | 14557.8 | 1 | UniProt (A0A045KJ85) Pfam (PF00453) UniProt (by SIFTS) (P9WHC5) | Mycobacterium tuberculosis | |
| 23 | W (R) | LSU ribosomal protein L21p | polymer | 104 | 11173.1 | 1 | UniProt (A0A1N6MHB1) Pfam (PF00829) UniProt (by SIFTS) (P9WHC3) | Mycobacterium tuberculosis | Ribosomal protein L21 (BL20) |
| 24 | X (S) | 50S ribosomal protein L22 | polymer | 197 | 20424.6 | 1 | UniProt (A0A045H760) Pfam (PF00237) UniProt (by SIFTS) (P9WHC1) | Mycobacterium tuberculosis | |
| 25 | Y (T) | 50S ribosomal protein L23 | polymer | 100 | 10976.8 | 1 | UniProt (A0A045J9M3) Pfam (PF00276) UniProt (by SIFTS) (P9WHB9) | Mycobacterium tuberculosis | |
| 26 | Z (U) | 50S ribosomal protein L24 | polymer | 105 | 11500.3 | 1 | UniProt (A0A045IXU4) Pfam (PF00467) Pfam (PF17136) UniProt (by SIFTS) (P9WHB7) | Mycobacterium tuberculosis | |
| 27 | AA (V) | 50S ribosomal protein L25 | polymer | 215 | 22466.2 | 1 | UniProt (A0A045JAK4) Pfam (PF01386) Pfam (PF14693) UniProt (by SIFTS) (P9WHB5) | Mycobacterium tuberculosis | General stress protein CTC |
| 28 | BA (W) | 50S ribosomal protein L27 | polymer | 86 | 8987.3 | 1 | UniProt (A0A045K0G1) Pfam (PF01016) UniProt (by SIFTS) (P9WHB3) | Mycobacterium tuberculosis | |
| 29 | CA (X) | 50S ribosomal protein L28 | polymer | 64 | 6920.1 | 1 | UniProt (A0A045IDB8) Pfam (PF00830) UniProt (by SIFTS) (P0DV54) | Mycobacterium tuberculosis | |
| 30 | DA (Y) | 50S ribosomal protein L29 | polymer | 77 | 8872.0 | 1 | UniProt (A0A045IQ64) Pfam (PF00831) UniProt (by SIFTS) (P9WHA7) | Mycobacterium tuberculosis | |
| 31 | EA (Z) | 50S ribosomal protein L30 | polymer | 65 | 7361.6 | 1 | UniProt (A0A045H4J2) Pfam (PF00327) UniProt (by SIFTS) (P9WHA3) | Mycobacterium tuberculosis | |
| 32 | FA (A) | N-({(5S)-2-oxo-3-[4-(1,3-thiazol-5-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)acetamide | non-polymer | 317.4 | 1 | Chemie (917) |
Sequence modifications
4: 1 - 37 (UniProt: A0A1L6JSF4)
L: 1 - 146 (UniProt: A0A0T7M0A0)
| PDB | External Database | Details |
|---|---|---|
| Val 1 | Met 1 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Val 1 | Met 1 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 31 |
| Total formula weight | 1458131.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 317.4 | |
| All* | Total formula weight | 1458448.8 |
