Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5V7Q

Cryo-EM structure of the large ribosomal subunit from Mycobacterium tuberculosis bound with a potent linezolid analog

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0003735	molecular_function	structural constituent of ribosome
0	0005840	cellular_component	ribosome
0	0006412	biological_process	translation
0	0015934	cellular_component	large ribosomal subunit
0	1990904	cellular_component	ribonucleoprotein complex
1	0003735	molecular_function	structural constituent of ribosome
1	0005737	cellular_component	cytoplasm
1	0005840	cellular_component	ribosome
1	0006412	biological_process	translation
1	1990904	cellular_component	ribonucleoprotein complex
2	0003735	molecular_function	structural constituent of ribosome
2	0005840	cellular_component	ribosome
2	0006412	biological_process	translation
2	1990904	cellular_component	ribonucleoprotein complex
3	0003735	molecular_function	structural constituent of ribosome
3	0005840	cellular_component	ribosome
3	0006412	biological_process	translation
3	0022625	cellular_component	cytosolic large ribosomal subunit
3	1990904	cellular_component	ribonucleoprotein complex
4	0003735	molecular_function	structural constituent of ribosome
4	0005737	cellular_component	cytoplasm
4	0005840	cellular_component	ribosome
4	0006412	biological_process	translation
4	1990904	cellular_component	ribonucleoprotein complex
6	0003723	molecular_function	RNA binding
6	0003735	molecular_function	structural constituent of ribosome
6	0005840	cellular_component	ribosome
6	0006412	biological_process	translation
6	0019843	molecular_function	rRNA binding
6	0046872	molecular_function	metal ion binding
6	1990904	cellular_component	ribonucleoprotein complex
C	0002181	biological_process	cytoplasmic translation
C	0003723	molecular_function	RNA binding
C	0003735	molecular_function	structural constituent of ribosome
C	0005840	cellular_component	ribosome
C	0005886	cellular_component	plasma membrane
C	0006412	biological_process	translation
C	0015934	cellular_component	large ribosomal subunit
C	0016740	molecular_function	transferase activity
C	0019843	molecular_function	rRNA binding
C	1990904	cellular_component	ribonucleoprotein complex
D	0003723	molecular_function	RNA binding
D	0003735	molecular_function	structural constituent of ribosome
D	0005829	cellular_component	cytosol
D	0005840	cellular_component	ribosome
D	0005886	cellular_component	plasma membrane
D	0006412	biological_process	translation
D	0019843	molecular_function	rRNA binding
D	0022625	cellular_component	cytosolic large ribosomal subunit
D	1990904	cellular_component	ribonucleoprotein complex
E	0003723	molecular_function	RNA binding
E	0003735	molecular_function	structural constituent of ribosome
E	0005829	cellular_component	cytosol
E	0005840	cellular_component	ribosome
E	0005886	cellular_component	plasma membrane
E	0006412	biological_process	translation
E	0019843	molecular_function	rRNA binding
E	1990904	cellular_component	ribonucleoprotein complex
F	0000049	molecular_function	tRNA binding
F	0003723	molecular_function	RNA binding
F	0003735	molecular_function	structural constituent of ribosome
F	0005840	cellular_component	ribosome
F	0005886	cellular_component	plasma membrane
F	0006412	biological_process	translation
F	0019843	molecular_function	rRNA binding
F	0022625	cellular_component	cytosolic large ribosomal subunit
F	1990904	cellular_component	ribonucleoprotein complex
G	0002181	biological_process	cytoplasmic translation
G	0003723	molecular_function	RNA binding
G	0003735	molecular_function	structural constituent of ribosome
G	0005840	cellular_component	ribosome
G	0005886	cellular_component	plasma membrane
G	0006412	biological_process	translation
G	0009274	cellular_component	peptidoglycan-based cell wall
G	0019843	molecular_function	rRNA binding
G	0022625	cellular_component	cytosolic large ribosomal subunit
G	1990904	cellular_component	ribonucleoprotein complex
H	0003723	molecular_function	RNA binding
H	0003735	molecular_function	structural constituent of ribosome
H	0005829	cellular_component	cytosol
H	0005840	cellular_component	ribosome
H	0005886	cellular_component	plasma membrane
H	0006412	biological_process	translation
H	0009274	cellular_component	peptidoglycan-based cell wall
H	0019843	molecular_function	rRNA binding
H	0022625	cellular_component	cytosolic large ribosomal subunit
H	1990904	cellular_component	ribonucleoprotein complex
J	0003729	molecular_function	mRNA binding
J	0003735	molecular_function	structural constituent of ribosome
J	0005829	cellular_component	cytosol
J	0005840	cellular_component	ribosome
J	0005886	cellular_component	plasma membrane
J	0006412	biological_process	translation
J	0009274	cellular_component	peptidoglycan-based cell wall
J	0017148	biological_process	negative regulation of translation
J	0022625	cellular_component	cytosolic large ribosomal subunit
J	1990904	cellular_component	ribonucleoprotein complex
K	0003723	molecular_function	RNA binding
K	0003735	molecular_function	structural constituent of ribosome
K	0005840	cellular_component	ribosome
K	0005886	cellular_component	plasma membrane
K	0006412	biological_process	translation
K	0015934	cellular_component	large ribosomal subunit
K	0019843	molecular_function	rRNA binding
K	0022625	cellular_component	cytosolic large ribosomal subunit
K	0070180	molecular_function	large ribosomal subunit rRNA binding
K	1990904	cellular_component	ribonucleoprotein complex
L	0003723	molecular_function	RNA binding
L	0003735	molecular_function	structural constituent of ribosome
L	0005840	cellular_component	ribosome
L	0005886	cellular_component	plasma membrane
L	0006412	biological_process	translation
L	0015934	cellular_component	large ribosomal subunit
L	0019843	molecular_function	rRNA binding
L	0022625	cellular_component	cytosolic large ribosomal subunit
L	1990904	cellular_component	ribonucleoprotein complex
M	0000049	molecular_function	tRNA binding
M	0003723	molecular_function	RNA binding
M	0003735	molecular_function	structural constituent of ribosome
M	0005840	cellular_component	ribosome
M	0005886	cellular_component	plasma membrane
M	0006412	biological_process	translation
M	0019843	molecular_function	rRNA binding
M	0022625	cellular_component	cytosolic large ribosomal subunit
M	1990904	cellular_component	ribonucleoprotein complex
N	0003735	molecular_function	structural constituent of ribosome
N	0005840	cellular_component	ribosome
N	0005886	cellular_component	plasma membrane
N	0006412	biological_process	translation
N	0009274	cellular_component	peptidoglycan-based cell wall
N	0022625	cellular_component	cytosolic large ribosomal subunit
N	1990904	cellular_component	ribonucleoprotein complex
O	0003723	molecular_function	RNA binding
O	0003735	molecular_function	structural constituent of ribosome
O	0005737	cellular_component	cytoplasm
O	0005840	cellular_component	ribosome
O	0006412	biological_process	translation
O	0008097	molecular_function	5S rRNA binding
O	0019843	molecular_function	rRNA binding
O	0022625	cellular_component	cytosolic large ribosomal subunit
O	1990904	cellular_component	ribonucleoprotein complex
P	0003735	molecular_function	structural constituent of ribosome
P	0005840	cellular_component	ribosome
P	0005886	cellular_component	plasma membrane
P	0006412	biological_process	translation
P	0022625	cellular_component	cytosolic large ribosomal subunit
P	1990904	cellular_component	ribonucleoprotein complex
Q	0000027	biological_process	ribosomal large subunit assembly
Q	0003723	molecular_function	RNA binding
Q	0003735	molecular_function	structural constituent of ribosome
Q	0005840	cellular_component	ribosome
Q	0005886	cellular_component	plasma membrane
Q	0006412	biological_process	translation
Q	0019843	molecular_function	rRNA binding
Q	0022625	cellular_component	cytosolic large ribosomal subunit
Q	1990904	cellular_component	ribonucleoprotein complex
R	0003723	molecular_function	RNA binding
R	0003735	molecular_function	structural constituent of ribosome
R	0005737	cellular_component	cytoplasm
R	0005840	cellular_component	ribosome
R	0005886	cellular_component	plasma membrane
R	0006412	biological_process	translation
R	0019843	molecular_function	rRNA binding
R	1990904	cellular_component	ribonucleoprotein complex
S	0003723	molecular_function	RNA binding
S	0003735	molecular_function	structural constituent of ribosome
S	0005840	cellular_component	ribosome
S	0006412	biological_process	translation
S	0009274	cellular_component	peptidoglycan-based cell wall
S	0015934	cellular_component	large ribosomal subunit
S	0019843	molecular_function	rRNA binding
S	0022625	cellular_component	cytosolic large ribosomal subunit
S	1990904	cellular_component	ribonucleoprotein complex
T	0003723	molecular_function	RNA binding
T	0003735	molecular_function	structural constituent of ribosome
T	0005829	cellular_component	cytosol
T	0005840	cellular_component	ribosome
T	0005886	cellular_component	plasma membrane
T	0006412	biological_process	translation
T	0019843	molecular_function	rRNA binding
T	0022625	cellular_component	cytosolic large ribosomal subunit
T	1990904	cellular_component	ribonucleoprotein complex
U	0003723	molecular_function	RNA binding
U	0003735	molecular_function	structural constituent of ribosome
U	0005840	cellular_component	ribosome
U	0006412	biological_process	translation
U	0009274	cellular_component	peptidoglycan-based cell wall
U	0019843	molecular_function	rRNA binding
U	0022625	cellular_component	cytosolic large ribosomal subunit
U	1990904	cellular_component	ribonucleoprotein complex
V	0003723	molecular_function	RNA binding
V	0003735	molecular_function	structural constituent of ribosome
V	0005829	cellular_component	cytosol
V	0005840	cellular_component	ribosome
V	0006412	biological_process	translation
V	0008097	molecular_function	5S rRNA binding
V	0019843	molecular_function	rRNA binding
V	0022625	cellular_component	cytosolic large ribosomal subunit
V	1990904	cellular_component	ribonucleoprotein complex
W	0003735	molecular_function	structural constituent of ribosome
W	0005840	cellular_component	ribosome
W	0005886	cellular_component	plasma membrane
W	0006412	biological_process	translation
W	0009274	cellular_component	peptidoglycan-based cell wall
W	0022625	cellular_component	cytosolic large ribosomal subunit
W	1990904	cellular_component	ribonucleoprotein complex
X	0003735	molecular_function	structural constituent of ribosome
X	0005840	cellular_component	ribosome
X	0006412	biological_process	translation
X	1990904	cellular_component	ribonucleoprotein complex
Y	0003735	molecular_function	structural constituent of ribosome
Y	0005840	cellular_component	ribosome
Y	0006412	biological_process	translation
Y	0022625	cellular_component	cytosolic large ribosomal subunit
Y	1990904	cellular_component	ribonucleoprotein complex
Z	0003735	molecular_function	structural constituent of ribosome
Z	0005840	cellular_component	ribosome
Z	0006412	biological_process	translation
Z	0015934	cellular_component	large ribosomal subunit
Z	0022625	cellular_component	cytosolic large ribosomal subunit
Z	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue 917 A 5001

Chain	Residue
A	G2299
A	C2690
A	A2741
A	U2742
A	G2743
A	U2744
A	U2823

Functional Information from PROSITE/UniProt

site_id	PS00049
Number of Residues	27
Details	RIBOSOMAL_L14 Ribosomal protein L14 signature. AVVVrtvkerrrp.DGsyikFdeNaaVI

Chain	Residue	Details
K	ALA60-ILE86

site_id	PS00050
Number of Residues	16
Details	RIBOSOMAL_L23 Ribosomal protein L23 signature. KRAIVTLApgsrpidL

Chain	Residue	Details
T	LYS80-LEU95

site_id	PS00464
Number of Residues	25
Details	RIBOSOMAL_L22 Ribosomal protein L22 signature. KriRpRAqGRafrirrrtSHITVvV

Chain	Residue	Details
S	LYS93-VAL117

site_id	PS00467
Number of Residues	12
Details	RIBOSOMAL_L2 Ribosomal protein L2 signature. PsvRGVVmNPvD

Chain	Residue	Details
C	PRO219-ASP230

site_id	PS00474
Number of Residues	24
Details	RIBOSOMAL_L3 Ribosomal protein L3 signature. FadgsyvDvtGtSkGKGfaGtmkR

Chain	Residue	Details
D	PHE106-ARG129

site_id	PS00475
Number of Residues	31
Details	RIBOSOMAL_L15 Ribosomal protein L15 signature. KVLGdGkLtak..VdVsahkFSgsArakItaaG

Chain	Residue	Details
L	LYS110-GLY140

site_id	PS00525
Number of Residues	9
Details	RIBOSOMAL_L6_1 Ribosomal protein L6 signature 1. PDpYKGKGV

Chain	Residue	Details
G	PRO155-VAL163

site_id	PS00579
Number of Residues	15
Details	RIBOSOMAL_L29 Ribosomal protein L29 signature. NNRRLRtVRQEIARI

Chain	Residue	Details
Y	ASN43-ILE57

site_id	PS00582
Number of Residues	20
Details	RIBOSOMAL_L33 Ribosomal protein L33 signature. YiTkKNrrndPdrLElkKFC

Chain	Residue	Details
1	TYR23-CYS42

site_id	PS00586
Number of Residues	12
Details	RIBOSOMAL_L16_1 Ribosomal protein L16 signature 1. KRgGKVWINIFP

Chain	Residue	Details
M	LYS59-PRO70

site_id	PS00634
Number of Residues	33
Details	RIBOSOMAL_L30 Ribosomal protein L30 signature. SLrtLgLrRirHsVirednaatrgLIavVrhLV

Chain	Residue	Details
Z	SER22-VAL54

site_id	PS00651
Number of Residues	28
Details	RIBOSOMAL_L9 Ribosomal protein L9 signature. GsiGdtveVkdGYgrNFLlprglAivaS

Chain	Residue	Details
H	GLY13-SER40

site_id	PS00701
Number of Residues	12
Details	RIBOSOMAL_L16_2 Ribosomal protein L16 signature 2. RMGsGKGspewW

Chain	Residue	Details
M	ARG82-TRP93

site_id	PS00783
Number of Residues	23
Details	RIBOSOMAL_L13 Ribosomal protein L13 signature. ILGMLPknrl.SRqiqrkLrVYaG

Chain	Residue	Details
J	ILE105-GLY127

site_id	PS00784
Number of Residues	20
Details	RIBOSOMAL_L34 Ribosomal protein L34 signature. KRTFQpnnrrRarvh.GFrlR

Chain	Residue	Details
2	LYS5-ARG24

site_id	PS00828
Number of Residues	26
Details	RIBOSOMAL_L36 Ribosomal protein L36 signature. CdkCrlIrRhgrVmViCsdp.RHkQrQ

Chain	Residue	Details
4	CYS11-GLN36

site_id	PS00831
Number of Residues	15
Details	RIBOSOMAL_L27 Ribosomal protein L27 signature. GeILvRQRGtkfhpG

Chain	Residue	Details
W	GLY34-GLY48

site_id	PS00936
Number of Residues	27
Details	RIBOSOMAL_L35 Ribosomal protein L35 signature. KTHsGAsKRFrrtgtgkivrqkanr.RH

Chain	Residue	Details
3	LYS5-HIS31

site_id	PS00937
Number of Residues	17
Details	RIBOSOMAL_L20 Ribosomal protein L20 signature. KgefRkLWIARINaaaR

Chain	Residue	Details
Q	LYS54-ARG70

site_id	PS01015
Number of Residues	16
Details	RIBOSOMAL_L19 Ribosomal protein L19 signature. VvTrGDVR.RAKLYYLR

Chain	Residue	Details
P	VAL85-ARG100

site_id	PS01108
Number of Residues	18
Details	RIBOSOMAL_L24 Ribosomal protein L24 signature. GDtVlVIsGkdKGak.GkV

Chain	Residue	Details
U	GLY6-VAL23

site_id	PS01143
Number of Residues	22
Details	RIBOSOMAL_L31 Ribosomal protein L31 signature. EVcsqcHPFYTgkqkildsg....GR

Chain	Residue	Details
6	GLU36-ARG57

site_id	PS01167
Number of Residues	23
Details	RIBOSOMAL_L17 Ribosomal protein L17 signature. ItTTepKaRalrpyaEkLIThAK

Chain	Residue	Details
N	ILE34-LYS56

site_id	PS01169
Number of Residues	23
Details	RIBOSOMAL_L21 Ribosomal protein L21 signature. IrihKfknKTgyhkrqGHRQqlT

Chain	Residue	Details
R	ILE74-THR96

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00501","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	108
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	22
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)