5V08
Crystal structure of human exonuclease 1 Exo1 (D173A) in complex with 5' recessed-end DNA (rVI)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (Z) | Exonuclease 1 | polymer | 352 | 39515.9 | 1 | UniProt (Q9UQ84) Pfam (PF00752) Pfam (PF00867) | Homo sapiens (Human) | hExo1, Exonuclease I, hExoI |
| 2 | B (A) | DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3') | polymer | 13 | 3951.6 | 1 | synthetic construct | ||
| 3 | C (B) | DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3') | polymer | 10 | 3045.0 | 1 | synthetic construct | ||
| 4 | D, F, G (Z, B) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 5 | E (Z) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | H, I, J (Z, A, B) | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
Z: 1 - 352 (UniProt: Q9UQ84)
| PDB | External Database | Details |
|---|---|---|
| Ala 173 | Asp 173 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 46512.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 95.9 | |
| All* | Total formula weight | 46608.4 |
