5UZS

Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P200

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Inosine-5'-monophosphate dehydrogenase	polymer	363	38482.3	4	UniProt (A0A0H2YRZ7) Pfam (PF00478)	Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)	IMPDH
2	E, J, Q, X (A, B, C, D)	INOSINIC ACID	non-polymer		348.2	4	Chemie (IMP)
3	F, K, R, Y (A, B, C, D)	3-(2-{[(4-chlorophenyl)carbamoyl]amino}propan-2-yl)-N-hydroxybenzene-1-carboximidamide	non-polymer		346.8	4	Chemie (8L4)
4	G, H, N, T, V (A, B, C)	TRIETHYLENE GLYCOL	non-polymer		150.2	5	Chemie (PGE)
5	AA, BA, I, L, S... (D, A, B, C)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	6	Chemie (PEG)
6	M, U (B, C)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
7	O (B)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
8	P, W (B, C)	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
9	CA (D)	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
10	DA, EA, FA, GA (A, B, C, D)	water	water		18.0	147	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 88 (UniProt: A0A0H2YRZ7)

PDB	External Database	Details
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag

A, B, C, D: 216 - 484 (UniProt: A0A0H2YRZ7)

PDB	External Database	Details
Ser 89	-	linker
Gly 90	-	linker
Gly 91	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	153929.2
Non-Polymers*	Number of molecules	25
	Total formula weight	4588.5
All*	Total formula weight	158517.7

*Water molecules are not included.