5UZC

Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P221

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Inosine-5'-monophosphate dehydrogenase	polymer	363	38441.3	4	UniProt (A0A0H2YRZ7) Pfam (PF00478)	Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)	IMPDH
2	E, J, N, R (A, B, C, D)	INOSINIC ACID	non-polymer		348.2	4	Chemie (IMP)
3	F, K, O, S (A, B, C, D)	N-{2-chloro-5-[({2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl}carbamoyl)amino]phenyl}-beta-D-xylofuranosylamine	non-polymer		476.0	4	Chemie (8N1)
4	G, L, T (A, B, D)	(4S)-2-METHYL-2,4-PENTANEDIOL	non-polymer		118.2	3	Chemie (MPD)
5	H, Q, U (A, C, D)	ACETIC ACID	non-polymer		60.1	3	Chemie (ACY)
6	I, M (A, B)	FORMIC ACID	non-polymer		46.0	2	Chemie (FMT)
7	P (C)	(4R)-2-METHYLPENTANE-2,4-DIOL	non-polymer		118.2	1	Chemie (MRD)
8	V, W, X, Y (A, B, C, D)	water	water		18.0	409	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 88 (UniProt: A0A0H2YRZ7)

PDB	External Database	Details
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag

A, B, C, D: 89 - 484 (UniProt: A0A0H2YRZ7)

PDB	External Database	Details
Ser 89	Lys 213	linker
Gly 90	Gly 214	linker
Gly 91	Arg 215	linker

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	153765.1
Non-Polymers*	Number of molecules	17
	Total formula weight	4041.6
All*	Total formula weight	157806.7

*Water molecules are not included.