5UXE

Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P178

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Inosine-5'-monophosphate dehydrogenase	polymer	363	38441.3	4	UniProt (A0A127ELD1)	Clostridium perfringens	IMPDH
2	E, H, M, Q (A, B, C, D)	INOSINIC ACID	non-polymer		348.2	4	Chemie (IMP) PubChem (177678963) PubChem (135464200) PubChem (135533971) PubChem (138454308) PubChem (135398640) PubChem (135402036) PubChem (135449337) PubChem (135486133) PubChem (135530792) PubChem (135567013) PubChem (135705234) PubChem (135854804) PubChem (135889742) PubChem (136026456) PubChem (136073920) PubChem (136217866) PubChem (136259539) PubChem (136716177) PubChem (136766861) PubChem (136811071) PubChem (137162990) PubChem (137168789) PubChem (137257909) PubChem (162510533) PubChem (174152734)
3	F, I, N, R (A, B, C, D)	N-[4-chloro-3-(alpha-D-ribofuranosyloxy)phenyl]-N'-{2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl}urea	non-polymer		476.9	4	Chemie (8LA) PubChem (124220274) PubChem (146637064)
4	G, K, P (A, B, D)	POTASSIUM ION	non-polymer		39.1	3	Chemie (K) PubChem (813)
5	J, S (B, D)	(4S)-2-METHYL-2,4-PENTANEDIOL	non-polymer		118.2	2	Chemie (MPD)
6	L (C)	FORMIC ACID	non-polymer		46.0	1	Chemie (FMT) PubChem (284)
7	O (C)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
8	T, U, V, W (A, B, C, D)	water	water		18.0	232	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 88 (UniProt: A0A127ELD1)

PDB	External Database	Details
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag

A, B, C, D: 216 - 484 (UniProt: A0A127ELD1)

PDB	External Database	Details
Ser 89	-	linker
Gly 90	-	linker
Gly 91	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	153765.1
Non-Polymers*	Number of molecules	15
	Total formula weight	3796.4
All*	Total formula weight	157561.4

*Water molecules are not included.