5UWJ
Crystal Structure of FMRP NES Peptide in complex with CRM1-Ran-RanBP1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GTP-binding nuclear protein Ran | polymer | 237 | 26758.6 | 1 | UniProt (P62826) Pfam (PF00071) | Homo sapiens (Human) | Androgen receptor-associated protein 24, GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein |
| 2 | B (B) | Ran-specific GTPase-activating protein 1 | polymer | 143 | 16521.9 | 1 | UniProt (P41920) Pfam (PF00638) | Saccharomyces cerevisiae (Baker's yeast) | Chromosome stability protein 20, Perinuclear array-localized protein, Ran-binding protein 1, RANBP1 |
| 3 | C (C) | Exportin-1 | polymer | 1024 | 117458.8 | 1 | UniProt (P30822) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767) | Saccharomyces cerevisiae (Baker's yeast) | Chromosome region maintenance protein 1, Karyopherin-124 |
| 4 | D (D) | Synaptic functional regulator FMR1 | polymer | 15 | 1919.2 | 1 | UniProt (by SIFTS) (Q06787) | Homo sapiens | |
| 5 | E (A) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
| 6 | F (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 7 | G, H, I (A, C) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 8 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 574 | Chemie (HOH) |
Sequence modifications
A: 1 - 216 (UniProt: P62826)
B: 62 - 201 (UniProt: P41920)
C: 1 - 376 (UniProt: P30822)
C: 414 - 1058 (UniProt: P30822)
| PDB | External Database | Details |
|---|---|---|
| Met -20 | - | expression tag |
| Glu -19 | - | expression tag |
| Thr -18 | - | expression tag |
| Gly -17 | - | expression tag |
| Ser -16 | - | expression tag |
| Ser -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 59 | - | expression tag |
| Gly 60 | - | expression tag |
| Ser 61 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp 441 | Val 441 | conflict |
| Gly 537 | Asp 537 | conflict |
| Cys 539 | Thr 539 | conflict |
| Glu 540 | Val 540 | conflict |
| Gln 541 | Lys 541 | conflict |
| Cys 1022 | Tyr 1022 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 162658.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 822.8 | |
| All* | Total formula weight | 163481.2 |
