5UWF
Crystal structure of human PDE10A in complex with inhibitor 16d
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (C, D) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 344 | 39482.3 | 2 | UniProt (Q9Y233) | Homo sapiens (Human) | |
| 2 | C, F (C, D) | 9-[(1S)-2,2-difluorocyclopropane-1-carbonyl]-6-[(4-methoxyphenyl)methyl]-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one | non-polymer | 471.5 | 2 | Chemie (8Q7) | |||
| 3 | D, G (C, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E, H (C, D) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | I, J (C, D) | water | water | 18.0 | 438 | Chemie (HOH) |
Sequence modifications
C, D: 449 - 789 (UniProt: Q9Y233)
| PDB | External Database | Details |
|---|---|---|
| Ser 446 | - | expression tag |
| Met 447 | - | expression tag |
| Ala 448 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 78964.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1122.4 | |
| All* | Total formula weight | 80087.0 |
