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5UWF

Crystal structure of human PDE10A in complex with inhibitor 16d

Functional Information from GO Data
ChainGOidnamespacecontents
C0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
C0007165biological_processsignal transduction
C0008081molecular_functionphosphoric diester hydrolase activity
D0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
D0007165biological_processsignal transduction
D0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue 8Q7 C 801
ChainResidue
CTYR524
CMET713
CGLN726
CPHE729
CHOH914
CHOH1051
DLYS705
DLEU706
DGLY707
DHOH1109
CHIS525
CLEU675
CSER677
CVAL678
CILE692
CTYR693
CPHE696
CILE711

site_idAC2
Number of Residues7
Detailsbinding site for residue ZN C 802
ChainResidue
CHIS529
CHIS563
CASP564
CASP674
CMG803
CHOH984
CHOH1025

site_idAC3
Number of Residues7
Detailsbinding site for residue MG C 803
ChainResidue
CASP564
CZN802
CHOH915
CHOH917
CHOH984
CHOH989
CHOH993

site_idAC4
Number of Residues14
Detailsbinding site for residue 8Q7 D 801
ChainResidue
DTYR524
DHIS525
DLEU675
DSER677
DVAL678
DILE692
DTYR693
DPHE696
DMET713
DGLN726
DPHE729
DVAL733
DHOH919
DHOH969

site_idAC5
Number of Residues5
Detailsbinding site for residue ZN D 802
ChainResidue
DHIS529
DHIS563
DASP564
DASP674
DHOH907

site_idAC6
Number of Residues6
Detailsbinding site for residue MG D 803
ChainResidue
DASP564
DHOH901
DHOH907
DHOH909
DHOH946
DHOH1008

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY
ChainResidueDetails
CHIS563-TYR574

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF
ChainResidueDetails
CCYS562
CGLU606
CGLY640
CGLN659
DCYS562
DGLU606
DGLY640
DGLN659

223532

PDB entries from 2024-08-07

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