5UV8

Interleukin-3 Receptor Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, G)	Interleukin-3 receptor subunit alpha	polymer	288	33253.6	2	UniProt (P26951) Pfam (PF18611) Pfam (PF09240)	Homo sapiens (Human)	IL-3RA
2	B, D (B, I)	Interleukin-3	polymer	122	13912.9	2	UniProt (P08700) Pfam (PF02059)	Homo sapiens (Human)	IL-3,Hematopoietic growth factor,Mast cell growth factor,MCGF,Multipotential colony-stimulating factor,P-cell-stimulating factor
3	E (C)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
4	F (D)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		732.7	1	In PDB GlyTouCan (G32152BH)
5	G (E)	beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		732.7	1	In PDB GlyTouCan (G27425HP)
6	H, L, M (A, G)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
7	I, J, K (G)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
8	N, O, P, Q (A, B, G, I)	water	water		18.0	100	Chemie (HOH)

Sequence modifications

A, G: 20 - 307 (UniProt: P26951)

PDB	External Database	Details
Gln 212	Asn 212	engineered mutation
Val 299	Ala 299	engineered mutation

B, I: 12 - 133 (UniProt: P08700)

PDB	External Database	Details
Tyr 13	Trp 32	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	94332.9
Branched	Number of molecules	3
	Total formula weight	2051.9
Non-Polymers*	Number of molecules	6
	Total formula weight	939.9
All*	Total formula weight	97324.8

*Water molecules are not included.