5UV8
Interleukin-3 Receptor Complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, G | Interleukin-3 receptor subunit alpha | polymer | 288 | 33253.6 | 2 | UniProt (P26951) Pfam (PF18611) Pfam (PF09240) In PDB | Homo sapiens (Human) | IL-3RA |
2 | B, I | Interleukin-3 | polymer | 122 | 13912.9 | 2 | UniProt (P08700) Pfam (PF02059) In PDB | Homo sapiens (Human) | IL-3,Hematopoietic growth factor,Mast cell growth factor,MCGF,Multipotential colony-stimulating factor,P-cell-stimulating factor |
3 | C | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
4 | D | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G32152BH) | |||
5 | E | beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G27425HP) | |||
6 | A, G | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
7 | G | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
8 | water | water | 18.0 | 100 | Chemie (HOH) |
Sequence modifications
A, G: 20 - 307 (UniProt: P26951)
B, I: 12 - 133 (UniProt: P08700)
PDB | External Database | Details |
---|---|---|
Gln 212 | Asn 212 | engineered mutation |
Val 299 | Ala 299 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Tyr 13 | Trp 32 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 94332.9 | |
Branched | Number of molecules | 3 |
Total formula weight | 2051.9 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 939.9 | |
All* | Total formula weight | 97324.8 |