5UT2

JAK2 JH2 in complex with PRT062607

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tyrosine-protein kinase JAK2	polymer	289	33121.0	1	UniProt (O60674) Pfam (PF07714)	Homo sapiens (Human)	Janus kinase 2,JAK-2
2	B, C (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
3	D (A)	2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-{[3-(2H-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide	non-polymer		393.4	1	Chemie (3YT)
4	E (A)	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
5	F (A)	water	water		18.0	273	Chemie (HOH)

Sequence modifications

A: 536 - 812 (UniProt: O60674)

PDB	External Database	Details
Ala 659	Trp 659	engineered mutation
Ala 777	Trp 777	engineered mutation
His 794	Phe 794	engineered mutation
Leu 813	-	expression tag
Val 814	-	expression tag
Pro 815	-	expression tag
Arg 816	-	expression tag
Gly 817	-	expression tag
Ser 818	-	expression tag
His 819	-	expression tag
His 820	-	expression tag
His 821	-	expression tag
His 822	-	expression tag
His 823	-	expression tag
His 824	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33121.0
Non-Polymers*	Number of molecules	4
	Total formula weight	636.7
All*	Total formula weight	33757.6

*Water molecules are not included.