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5UT2

JAK2 JH2 in complex with PRT062607

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue GOL A 901
ChainResidue
AASN673
AARG715
ATRP718
AHOH1001
AHOH1019
AHOH1066

site_idAC2
Number of Residues3
Detailsbinding site for residue GOL A 902
ChainResidue
APHE694
AHOH1067
AHOH1085

site_idAC3
Number of Residues15
Detailsbinding site for residue 3YT A 903
ChainResidue
ALEU551
AILE559
ALEU579
AGLU627
APHE628
AVAL629
ALYS630
AGLY632
ASER633
ALEU680
AHOH1024
AHOH1065
AHOH1087
AHOH1102
AHOH1116

site_idAC4
Number of Residues4
Detailsbinding site for residue ACT A 904
ChainResidue
AGLY619
AASP620
AGLU621
AASN622

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Breakpoint for translocation to form PCM1-JAK2 fusion protein
ChainResidueDetails
AASP710

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATYR570

227344

PDB entries from 2024-11-13

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