5UQV

USP7 in complex with GNE6640 (4-(2-amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl)phenol)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Ubiquitin carboxyl-terminal hydrolase 7	polymer	368	42477.0	2	UniProt (Q93009) Pfam (PF00443)	Homo sapiens (Human)	Deubiquitinating enzyme 7,Herpesvirus-associated ubiquitin-specific protease,Ubiquitin thioesterase 7,Ubiquitin-specific-processing protease 7
2	C, D (A, B)	4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl]phenol	non-polymer		330.4	2	Chemie (8JM)

Sequence modifications

A, B: 208 - 554 (UniProt: Q93009)

PDB	External Database	Details
Met 187	-	initiating methionine
Gly 188	-	expression tag
Ser 189	-	expression tag
Ser 190	-	expression tag
His 191	-	expression tag
His 192	-	expression tag
His 193	-	expression tag
His 194	-	expression tag
His 195	-	expression tag
His 196	-	expression tag
Ser 197	-	expression tag
Ser 198	-	expression tag
Gly 199	-	expression tag
Leu 200	-	expression tag
Val 201	-	expression tag
Pro 202	-	expression tag
Arg 203	-	expression tag
Gly 204	-	expression tag
Ser 205	-	expression tag
His 206	-	expression tag
Met 207	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	84953.9
Non-Polymers*	Number of molecules	2
	Total formula weight	660.8
All*	Total formula weight	85614.7

*Water molecules are not included.