5UQV

USP7 in complex with GNE6640 (4-(2-amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl)phenol)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0016579	biological_process	protein deubiquitination
B	0004843	molecular_function	cysteine-type deubiquitinase activity
B	0016579	biological_process	protein deubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue 8JM A 601

Chain	Residue
A	GLN297
A	GLN405
A	CYS300
A	LEU304
A	ASP305
A	GLU308
A	ILE320
A	TYR348
A	ASP349
A	HIS403

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site_id	AC2
Number of Residues	10
Details	binding site for residue 8JM B 601

Chain	Residue
B	GLN297
B	CYS300
B	LEU304
B	ASP305
B	GLU308
B	ILE320
B	TYR348
B	ASP349
B	HIS403
B	GLN405

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Functional Information from PROSITE/UniProt

site_id	PS00972
Number of Residues	16
Details	USP_1 Ubiquitin specific protease (USP) domain signature 1. GLknqGAtCYMNSlLQ

Chain	Residue	Details
A	GLY215-GLN230

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site_id	PS00973
Number of Residues	18
Details	USP_2 Ubiquitin specific protease (USP) domain signature 2. YiLhAVlvHsGdnhg..GHY

Chain	Residue	Details
A	TYR448-TYR465

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:12507430, ECO:0000269|PubMed:25944111, ECO:0000305|PubMed:11923872, ECO:0000305|PubMed:15053880, ECO:0000305|PubMed:16964248, ECO:0000305|PubMed:18716620, ECO:0000305|PubMed:21745816, ECO:0000305|PubMed:22411829

Chain	Residue	Details
A	ARG239
B	ARG239

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000305|PubMed:12507430

Chain	Residue	Details
A	PHE480
B	PHE480

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 789

Chain	Residue	Details
A	PHE234	electrostatic stabiliser
A	ARG239	nucleofuge, nucleophile, proton acceptor, proton donor
A	PHE480	proton acceptor, proton donor
A	ASN497	electrostatic stabiliser

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site_id	MCSA2
Number of Residues	4
Details	M-CSA 789

Chain	Residue	Details
B	PHE234	electrostatic stabiliser
B	ARG239	nucleofuge, nucleophile, proton acceptor, proton donor
B	PHE480	proton acceptor, proton donor
B	ASN497	electrostatic stabiliser

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