5UQH
Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Campylobacter jejuni in the complex with inhibitor p182
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase | polymer | 406 | 43524.8 | 8 | UniProt (A0A1B3XFT6) UniProt (A5KFK9) In PDB | Campylobacter jejuni subsp. jejuni | IMPDH |
2 | F, G, A, B, H... | INOSINIC ACID | non-polymer | 348.2 | 8 | Chemie (IMP) | |||
3 | F, G, A, H, B... | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) | |||
4 | F, G, B, H, C... | N-{4-chloro-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]phenyl}-N'-(2-{3-[(1E)-N-hydroxyethanimidoyl]phenyl}propan-2-yl)urea | non-polymer | 496.9 | 8 | Chemie (8L1) | |||
5 | F, D, E | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
6 | G | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 1 | Chemie (IPA) | |||
7 | water | water | 18.0 | 593 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 194 (UniProt: A0A1B3XFT6)
A, B, C, D, E, F, G, H: 196 - 485 (UniProt: A5KFK9)
PDB | External Database | Details |
---|---|---|
Met -23 | - | initiating methionine |
His -22 | - | expression tag |
His -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
Ser -16 | - | expression tag |
Ser -15 | - | expression tag |
Gly -14 | - | expression tag |
Val -13 | - | expression tag |
Asp -12 | - | expression tag |
Leu -11 | - | expression tag |
Gly -10 | - | expression tag |
Thr -9 | - | expression tag |
Glu -8 | - | expression tag |
Asn -7 | - | expression tag |
Leu -6 | - | expression tag |
Tyr -5 | - | expression tag |
Phe -4 | - | expression tag |
Gln -3 | - | expression tag |
Ser -2 | - | expression tag |
Asn -1 | - | expression tag |
Ala 0 | - | expression tag |
Gly 195 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 348198.6 | |
Non-Polymers* | Number of molecules | 30 |
Total formula weight | 7444.3 | |
All* | Total formula weight | 355642.9 |