5UQH
Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Campylobacter jejuni in the complex with inhibitor p182
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase | polymer | 406 | 43524.8 | 8 | UniProt (A0A1B3XFT6) UniProt (A5KFK9) | Campylobacter jejuni subsp. jejuni | IMPDH |
| 2 | BA, GA, I, K, KA... (F, G, A, B, H...) | INOSINIC ACID | non-polymer | 348.2 | 8 | Chemie (IMP) PubChem (177678963) PubChem (135464200) PubChem (135533971) PubChem (138454308) PubChem (135398640) PubChem (135402036) PubChem (135449337) PubChem (135486133) PubChem (135530792) PubChem (135567013) PubChem (135705234) PubChem (135854804) PubChem (135889742) PubChem (136026456) PubChem (136073920) PubChem (136217866) PubChem (136259539) PubChem (136716177) PubChem (136766861) PubChem (136811071) PubChem (137162990) PubChem (137168789) PubChem (137257909) PubChem (162510533) PubChem (174152734) | |||
| 3 | AA, FA, J, JA, M... (F, G, A, H, B...) | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) PubChem (813) | |||
| 4 | CA, HA, L, LA, O... (F, G, B, H, C...) | N-{4-chloro-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]phenyl}-N'-(2-{3-[(1E)-N-hydroxyethanimidoyl]phenyl}propan-2-yl)urea | non-polymer | 496.9 | 8 | Chemie (8L1) PubChem (124219490) PubChem (124222457) | |||
| 5 | DA, EA, U, X, Y (F, D, E) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 6 | IA (G) | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 1 | Chemie (IPA) | |||
| 7 | MA, NA, OA, PA, QA... (A, B, C, D, E...) | water | water | 18.0 | 593 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 194 (UniProt: A0A1B3XFT6)
A, B, C, D, E, F, G, H: 196 - 485 (UniProt: A5KFK9)
| PDB | External Database | Details |
|---|---|---|
| Met -23 | - | initiating methionine |
| His -22 | - | expression tag |
| His -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| Ser -16 | - | expression tag |
| Ser -15 | - | expression tag |
| Gly -14 | - | expression tag |
| Val -13 | - | expression tag |
| Asp -12 | - | expression tag |
| Leu -11 | - | expression tag |
| Gly -10 | - | expression tag |
| Thr -9 | - | expression tag |
| Glu -8 | - | expression tag |
| Asn -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Phe -4 | - | expression tag |
| Gln -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Gly 195 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 348198.6 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 7444.3 | |
| All* | Total formula weight | 355642.9 |
