5UQH
Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Campylobacter jejuni in the complex with inhibitor p182
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase | polymer | 406 | 43524.8 | 8 | UniProt (A0A1B3XFT6) UniProt (A5KFK9) | Campylobacter jejuni subsp. jejuni | IMPDH |
| 2 | BA, GA, I, K, KA... (F, G, A, B, H...) | INOSINIC ACID | non-polymer | 348.2 | 8 | Chemie (IMP) | |||
| 3 | AA, FA, J, JA, M... (F, G, A, H, B...) | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) | |||
| 4 | CA, HA, L, LA, O... (F, G, B, H, C...) | N-{4-chloro-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]phenyl}-N'-(2-{3-[(1E)-N-hydroxyethanimidoyl]phenyl}propan-2-yl)urea | non-polymer | 496.9 | 8 | Chemie (8L1) | |||
| 5 | DA, EA, U, X, Y (F, D, E) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 6 | IA (G) | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 1 | Chemie (IPA) | |||
| 7 | MA, NA, OA, PA, QA... (A, B, C, D, E...) | water | water | 18.0 | 593 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 194 (UniProt: A0A1B3XFT6)
A, B, C, D, E, F, G, H: 196 - 485 (UniProt: A5KFK9)
| PDB | External Database | Details |
|---|---|---|
| Met -23 | - | initiating methionine |
| His -22 | - | expression tag |
| His -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| Ser -16 | - | expression tag |
| Ser -15 | - | expression tag |
| Gly -14 | - | expression tag |
| Val -13 | - | expression tag |
| Asp -12 | - | expression tag |
| Leu -11 | - | expression tag |
| Gly -10 | - | expression tag |
| Thr -9 | - | expression tag |
| Glu -8 | - | expression tag |
| Asn -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Phe -4 | - | expression tag |
| Gln -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Gly 195 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 348198.6 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 7444.3 | |
| All* | Total formula weight | 355642.9 |
