5UQ0

FGFR1 kinase domain complex with fragment 2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Fibroblast growth factor receptor 1	polymer	311	35353.6	2	UniProt (P11362) Pfam (PF07714)	Homo sapiens (Human)	FGFR-1,Basic fibroblast growth factor receptor 1,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr
2	C, D (A, B)	2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carboxamide	non-polymer		191.2	2	Chemie (WP1)
3	E, F (A, B)	water	water		18.0	7	Chemie (HOH)

Sequence modifications

A, B: 459 - 765 (UniProt: P11362)

PDB	External Database	Details
Gly 455	-	expression tag
Ala 456	-	expression tag
Met 457	-	expression tag
Ser 458	-	expression tag
Ala 488	Cys 486	engineered mutation
Ser 584	Cys 582	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70707.2
Non-Polymers*	Number of molecules	2
	Total formula weight	382.5
All*	Total formula weight	71089.7

*Water molecules are not included.