5UPY

Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Listeria Monocytogenes in the complex with IMP and Q21

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Inosine-5'-monophosphate dehydrogenase	polymer	364	38455.9	1	UniProt (Q926Y9) Pfam (PF00478)	Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)	IMPDH
2	B (A)	INOSINIC ACID	non-polymer		348.2	1	Chemie (IMP) PubChem (177678963) PubChem (135464200) PubChem (135533971) PubChem (138454308) PubChem (135398640) PubChem (135402036) PubChem (135449337) PubChem (135486133) PubChem (135530792) PubChem (135567013) PubChem (135705234) PubChem (135854804) PubChem (135889742) PubChem (136026456) PubChem (136073920) PubChem (136217866) PubChem (136259539) PubChem (136716177) PubChem (136766861) PubChem (136811071) PubChem (137162990) PubChem (137168789) PubChem (137257909) PubChem (162510533) PubChem (174152734)
3	C (A)	(2S)-2-(naphthalen-1-yloxy)-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]propanamide	non-polymer		409.4	1	Chemie (Q21) PubChem (70851038) PubChem (71662080) PubChem (71297189)
4	D (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL) PubChem (312)
5	E, F, G (A)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL) PubChem (753)
6	H, I, J (A)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
7	K (A)	water	water		18.0	104	Chemie (HOH)

Sequence modifications

A: 1 - 91 (UniProt: Q926Y9)

PDB	External Database	Details
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag

A: 221 - 488 (UniProt: Q926Y9)

PDB	External Database	Details
Gly 92	-	linker
Gly 93	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	38455.9
Non-Polymers*	Number of molecules	9
	Total formula weight	1255.6
All*	Total formula weight	39711.5

*Water molecules are not included.