5UPF
Crystal structure of human NAMPT with isoindoline urea inhibitor compound 53
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Nicotinamide phosphoribosyltransferase | polymer | 499 | 56591.9 | 2 | UniProt (P43490) Pfam (PF18127) Pfam (PF04095) In PDB | Homo sapiens (Human) | Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin |
| 2 | A, B | 5-fluoro-N-{4-[1-(2-hydroxy-2-methylpropanoyl)piperidin-4-yl]phenyl}-2H-isoindole-2-carboxamide | non-polymer | 423.5 | 2 | Chemie (8HV) | |||
| 3 | water | water | 18.0 | 777 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 491 (UniProt: P43490)
| PDB | External Database | Details |
|---|---|---|
| Asp 492 | - | expression tag |
| Tyr 493 | - | expression tag |
| Lys 494 | - | expression tag |
| Asp 495 | - | expression tag |
| Asp 496 | - | expression tag |
| Asp 497 | - | expression tag |
| Asp 498 | - | expression tag |
| Lys 499 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 113183.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 847.0 | |
| All* | Total formula weight | 114030.8 |
