5UJA

Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1) bound to leukotriene C4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	bovine multidrug resistance protein 1 (MRP1),Multidrug resistance-associated protein 1	polymer	1460	159701.9	1	UniProt (Q8HXQ5) Pfam (PF00664) Pfam (PF00005)	Bos taurus	ATP-binding cassette sub-family C member 1,Leukotriene C(4) transporter,LTC4 transporter
2	B (A)	(5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-( 2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid	non-polymer		625.8	1	Chemie (LTX) PubChem (3907) PubChem (439669) PubChem (5353716) PubChem (6535391) PubChem (11467746) PubChem (13669254) PubChem (44208905) PubChem (44342241) PubChem (44563898) PubChem (177397197) PubChem (177693067) PubChem (51516) PubChem (5280493) PubChem (92223558) PubChem (5283121) PubChem (5283134) PubChem (99639299) PubChem (99639298) PubChem (125183211) PubChem (134688195) PubChem (92223560) PubChem (92223561) PubChem (92846391) PubChem (95065615) PubChem (99735773) PubChem (124576952) PubChem (124824522) PubChem (125183210) PubChem (129360334) PubChem (129360335) PubChem (134689689) PubChem (163078426) PubChem (169423504) PubChem (172873536)

Sequence modifications

A: 31 - 194 (PDB: 5UJA)
A: 205 - 1530 (UniProt: Q8HXQ5)

PDB	External Database	Details
Ser 1531	-	expression tag
Asn 1532	-	expression tag
Ser 1533	-	expression tag
Leu 1534	-	expression tag
Glu 1535	-	expression tag
Val 1536	-	expression tag
Leu 1537	-	expression tag
Phe 1538	-	expression tag
Gln 1539	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	159701.9
Non-Polymers*	Number of molecules	1
	Total formula weight	625.8
All*	Total formula weight	160327.7

*Water molecules are not included.