5UIW
Crystal Structure of CC Chemokine Receptor 5 (CCR5) in complex with high potency HIV entry inhibitor 5P7-CCL5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | C-C chemokine receptor type 5,Rubredoxin chimera | polymer | 411 | 47158.8 | 1 | UniProt (P51681) UniProt (P00268) Pfam (PF00001) Pfam (PF00301) | Homo sapiens (Human) | CCR5,CHEMR13,HIV-1 fusion coreceptor,Rd,CCR5,CHEMR13,HIV-1 fusion coreceptor |
| 2 | B (B) | C-C motif chemokine 5 | polymer | 75 | 8662.1 | 1 | UniProt (P13501) Pfam (PF00048) | Homo sapiens (Human) | EoCP,Eosinophil chemotactic cytokine,SIS-delta,Small-inducible cytokine A5,T cell-specific protein P228,TCP228,T-cell-specific protein RANTES |
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D, E, F, G, H... (A) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 6 | Chemie (OLC) | |||
| 5 | J, K (A) | OLEIC ACID | non-polymer | 282.5 | 2 | Chemie (OLA) | |||
| 6 | L, M (A, B) | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
A: 2 - 223 (UniProt: P51681)
A: 1001 - 1054 (UniProt: P00268)
A: 227 - 349 (UniProt: P51681)
B: 10 - 68 (UniProt: P13501)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Pro 1 | - | expression tag |
| Tyr 58 | Cys 58 | engineered mutation |
| Asn 163 | Gly 163 | engineered mutation |
A: 227 - 349 (UniProt: P51681)
| PDB | External Database | Details |
|---|---|---|
| Asp 233 | Ala 233 | engineered mutation |
| Glu 303 | Lys 303 | engineered mutation |
| - | Ala 317 | deletion |
| - | Lys 318 | deletion |
| - | Arg 319 | deletion |
| Gly 350 | - | expression tag |
| Arg 351 | - | expression tag |
| Pro 352 | - | expression tag |
| Leu 353 | - | expression tag |
| Glu 354 | - | expression tag |
| Val 355 | - | expression tag |
| Leu 356 | - | expression tag |
| Phe 357 | - | expression tag |
| Gln 358 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Pca 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Pro 2 | - | expression tag |
| Pro 3 | - | expression tag |
| Leu 4 | - | expression tag |
| Met 5 | - | expression tag |
| Ala 6 | - | expression tag |
| Leu 7 | - | expression tag |
| Gln 8 | - | expression tag |
| Ser 9 | - | expression tag |
| Leu 69 | - | expression tag |
| Glu 70 | - | expression tag |
| Val 71 | - | expression tag |
| Leu 72 | - | expression tag |
| Phe 73 | - | expression tag |
| Gln 74 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 55820.9 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2769.6 | |
| All* | Total formula weight | 58590.5 |
