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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5UIW

Crystal Structure of CC Chemokine Receptor 5 (CCR5) in complex with high potency HIV entry inhibitor 5P7-CCL5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004950	molecular_function	chemokine receptor activity
A	0005506	molecular_function	iron ion binding
A	0006935	biological_process	chemotaxis
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0016493	molecular_function	C-C chemokine receptor activity
A	0043448	biological_process	alkane catabolic process
A	0046872	molecular_function	metal ion binding
B	0005576	cellular_component	extracellular region
B	0006955	biological_process	immune response
B	0008009	molecular_function	chemokine activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1101

Chain	Residue
A	CYS1006
A	CYS1009
A	CYS1039
A	CYS1042

site_id	AC2
Number of Residues	6
Details	binding site for residue OLC A 1102

Chain	Residue
A	HOH1230
A	PHE189
A	ASN192
A	PHE193
A	LEU196
A	OLC1107

site_id	AC3
Number of Residues	1
Details	binding site for residue OLC A 1103

Chain	Residue
A	PHE85

site_id	AC4
Number of Residues	3
Details	binding site for residue OLC A 1104

Chain	Residue
A	ALA249
A	LEU266
A	ARG274

site_id	AC5
Number of Residues	2
Details	binding site for residue OLC A 1105

Chain	Residue
A	GLN277
A	ALA278

site_id	AC6
Number of Residues	2
Details	binding site for residue OLC A 1106

Chain	Residue
A	SER38
A	HIS88

site_id	AC7
Number of Residues	6
Details	binding site for residue OLC A 1107

Chain	Residue
A	ASN24
A	ILE28
A	LEU32
A	PHE189
A	GLN277
A	OLC1102

site_id	AC8
Number of Residues	2
Details	binding site for residue OLA A 1108

Chain	Residue
A	ARG235
A	OLA1109

site_id	AC9
Number of Residues	2
Details	binding site for residue OLA A 1109

Chain	Residue
A	ILE242
A	OLA1108

Functional Information from PROSITE/UniProt

site_id	PS00202
Number of Residues	11
Details	RUBREDOXIN Rubredoxin signature. IpDDWvCPlCG

Chain	Residue	Details
A	ILE1033-GLY1043

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SGIfFIILLTIDRYLaV

Chain	Residue	Details
A	SER114-VAL130

site_id	PS00472
Number of Residues	42
Details	SMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCFayiarp..LprahIkeYfytsgk..Csnp.AVVFvtrknrqv.CA

Chain	Residue	Details
B	CYS10-ALA51

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Methionine sulfoxide => ECO:0000269\|PubMed:1380064

Chain	Residue	Details
B	MET67

site_id	SWS_FT_FI2
Number of Residues	75
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	LYS59-TYR68
A	ASP125-THR141
A	GLU302-PRO352

site_id	SWS_FT_FI3
Number of Residues	20
Details	TRANSMEM: Helical; Name=2 => ECO:0000255

Chain	Residue	Details
A	LEU69-TYR89

site_id	SWS_FT_FI4
Number of Residues	59
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	ALA90-GLN102
A	THR167-ILE198
A	GLN261-GLN277

site_id	SWS_FT_FI5
Number of Residues	21
Details	TRANSMEM: Helical; Name=3 => ECO:0000255

Chain	Residue	Details
A	LEU103-ILE124

site_id	SWS_FT_FI6
Number of Residues	24
Details	TRANSMEM: Helical; Name=4 => ECO:0000255

Chain	Residue	Details
A	VAL142-PHE166

site_id	SWS_FT_FI7
Number of Residues	19
Details	TRANSMEM: Helical; Name=5 => ECO:0000255

Chain	Residue	Details
A	VAL199-LEU218

site_id	SWS_FT_FI8
Number of Residues	24
Details	TRANSMEM: Helical; Name=6 => ECO:0000255

Chain	Residue	Details
A	LEU236-PHE260

site_id	SWS_FT_FI9
Number of Residues	23
Details	TRANSMEM: Helical; Name=7 => ECO:0000255

Chain	Residue	Details
A	ALA278-GLY301

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Sulfotyrosine => ECO:0000269\|PubMed:10089882

Chain	Residue	Details
A	TYR3

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Sulfotyrosine => ECO:0000269\|PubMed:21763489

Chain	Residue	Details
A	TYR10
A	TYR14

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Sulfotyrosine => ECO:0000255

Chain	Residue	Details
A	TYR15

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphoserine; by BARK1 => ECO:0000269\|PubMed:10085131

Chain	Residue	Details
A	TYR336
A	THR337
A	GLU342
A	LEU349

site_id	SWS_FT_FI14
Number of Residues	3
Details	LIPID: S-palmitoyl cysteine => ECO:0000269\|PubMed:11323418

Chain	Residue	Details
A	CYS321
A	ILE323
A	PHE324

site_id	SWS_FT_FI15
Number of Residues	2
Details	CARBOHYD: O-linked (GalNAc...) serine => ECO:0000269\|PubMed:11733580

Chain	Residue	Details
A	SER6
A	SER7

site_id	SWS_FT_FI16
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00241, ECO:0000269\|PubMed:10216292

Chain	Residue	Details
A	CYS1006
A	CYS1009
A	CYS1039
A	CYS1042

site_id	SWS_FT_FI17
Number of Residues	1
Details	MOD_RES: N-formylmethionine => ECO:0000269\|PubMed:1637309

Chain	Residue	Details
A	MET1001

227111

PDB entries from 2024-11-06

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