5UIP
structure of DHFR with bound DAP, p-ABG and NADP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dihydrofolate reductase | polymer | 163 | 18157.3 | 2 | UniProt (P0ABQ4) Pfam (PF00186) | Escherichia coli | |
| 2 | C, G (A, B) | N-(4-aminobenzene-1-carbonyl)-L-glutamic acid | non-polymer | 266.3 | 2 | Chemie (8DM) PubChem (38988600) PubChem (65138) PubChem (196473) | |||
| 3 | D, H (A, B) | PYRIMIDINE-2,4-DIAMINE | non-polymer | 110.1 | 2 | Chemie (LG3) PubChem (67431) | |||
| 4 | E, I (A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) PubChem (4412) PubChem (46936685) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (71717786) PubChem (5885) PubChem (165382010) | |||
| 5 | F, J (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) PubChem (923) | |||
| 6 | K, L (A, B) | water | water | 18.0 | 388 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 159 (UniProt: P0ABQ4)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ser 152 | Cys 152 | engineered mutation |
| Gly 160 | - | expression tag |
| Gly 161 | - | expression tag |
| Gly 162 | - | expression tag |
| Gly 163 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36314.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2285.5 | |
| All* | Total formula weight | 38600.2 |
