5UIP
structure of DHFR with bound DAP, p-ABG and NADP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Dihydrofolate reductase | polymer | 163 | 18157.3 | 2 | UniProt (P0ABQ4) Pfam (PF00186) In PDB | Escherichia coli | |
| 2 | A, B | N-(4-aminobenzene-1-carbonyl)-L-glutamic acid | non-polymer | 266.3 | 2 | Chemie (8DM) | |||
| 3 | A, B | PYRIMIDINE-2,4-DIAMINE | non-polymer | 110.1 | 2 | Chemie (LG3) | |||
| 4 | A, B | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 5 | A, B | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 6 | water | water | 18.0 | 388 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 159 (UniProt: P0ABQ4)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ser 152 | Cys 152 | engineered mutation |
| Gly 160 | - | expression tag |
| Gly 161 | - | expression tag |
| Gly 162 | - | expression tag |
| Gly 163 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36314.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2285.5 | |
| All* | Total formula weight | 38600.2 |
