5UGL

Crystal Structure of FGF Receptor 2 Tyrosine Kinase Domain Harboring the D650V Activating Mutation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, A)	Fibroblast growth factor receptor 2	polymer	324	37094.6	2	UniProt (P21802) Pfam (PF07714)	Homo sapiens (Human)	FGFR-2,K-sam,KGFR,Keratinocyte growth factor receptor
2	C, E (B, A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	D, F (B, A)	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	2	Chemie (ANP)
4	G, H (B, A)	water	water		18.0	182	Chemie (HOH)

Sequence modifications

B, A: 458 - 768 (UniProt: P21802)

PDB	External Database	Details
Met 445	-	initiating methionine
Gly 446	-	expression tag
Ser 447	-	expression tag
Ser 448	-	expression tag
His 449	-	expression tag
His 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag
Ser 455	-	expression tag
Gln 456	-	expression tag
Asp 457	-	expression tag
Ala 491	Cys 374	conflict
Val 650	Asp 533	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74189.3
Non-Polymers*	Number of molecules	4
	Total formula weight	1204.5
All*	Total formula weight	75393.8

*Water molecules are not included.