5UDC
Crystal Structure of RSV F A2 Bound to MEDI8897
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | H, B, E | MEDI8897 Fab Heavy Chain | polymer | 228 | 24157.1 | 3 | Homo sapiens | ||
2 | L, C, G | MEDI8897 Fab Light Chain | polymer | 214 | 23325.9 | 3 | Homo sapiens | ||
3 | F, A, D | Fusion glycoprotein F0 | polymer | 568 | 63218.3 | 3 | UniProt (P03420) Pfam (PF00523) In PDB | Human respiratory syncytial virus A (strain A2) | Protein F |
4 | I | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1883.7 | 1 | In PDB GlyTouCan (G60230HH) | |||
5 | F, A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) |
Sequence modifications
F, A, D: 1 - 513 (UniProt: P03420)
PDB | External Database | Details |
---|---|---|
Ala 102 | Pro 102 | conflict |
Cys 155 | Ser 155 | engineered mutation |
Phe 190 | Ser 190 | engineered mutation |
Leu 207 | Val 207 | engineered mutation |
Cys 290 | Ser 290 | engineered mutation |
Val 379 | Ile 379 | conflict |
Val 447 | Met 447 | conflict |
Ser 514 | - | expression tag |
Ala 515 | - | expression tag |
Ile 516 | - | expression tag |
Gly 517 | - | expression tag |
Gly 518 | - | expression tag |
Tyr 519 | - | expression tag |
Ile 520 | - | expression tag |
Pro 521 | - | expression tag |
Glu 522 | - | expression tag |
Ala 523 | - | expression tag |
Pro 524 | - | expression tag |
Arg 525 | - | expression tag |
Asp 526 | - | expression tag |
Gly 527 | - | expression tag |
Gln 528 | - | expression tag |
Ala 529 | - | expression tag |
Tyr 530 | - | expression tag |
Val 531 | - | expression tag |
Arg 532 | - | expression tag |
Lys 533 | - | expression tag |
Asp 534 | - | expression tag |
Gly 535 | - | expression tag |
Glu 536 | - | expression tag |
Trp 537 | - | expression tag |
Val 538 | - | expression tag |
Leu 539 | - | expression tag |
Leu 540 | - | expression tag |
Ser 541 | - | expression tag |
Thr 542 | - | expression tag |
Phe 543 | - | expression tag |
Leu 544 | - | expression tag |
Gly 545 | - | expression tag |
Gly 546 | - | expression tag |
Leu 547 | - | expression tag |
Val 548 | - | expression tag |
Pro 549 | - | expression tag |
Arg 550 | - | expression tag |
Gly 551 | - | expression tag |
Ser 552 | - | expression tag |
His 553 | - | expression tag |
His 554 | - | expression tag |
His 555 | - | expression tag |
His 556 | - | expression tag |
His 557 | - | expression tag |
His 558 | - | expression tag |
Ser 559 | - | expression tag |
Ala 560 | - | expression tag |
Trp 561 | - | expression tag |
Ser 562 | - | expression tag |
His 563 | - | expression tag |
Pro 564 | - | expression tag |
Gln 565 | - | expression tag |
Phe 566 | - | expression tag |
Glu 567 | - | expression tag |
Lys 568 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 9 |
Total formula weight | 332103.8 | |
Branched | Number of molecules | 1 |
Total formula weight | 1883.7 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 70.9 | |
All* | Total formula weight | 334058.4 |