5UDC
Crystal Structure of RSV F A2 Bound to MEDI8897
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G (H, B, E) | MEDI8897 Fab Heavy Chain | polymer | 228 | 24157.1 | 3 | Homo sapiens | ||
| 2 | B, E, H (L, C, G) | MEDI8897 Fab Light Chain | polymer | 214 | 23325.9 | 3 | Homo sapiens | ||
| 3 | C, F, I (F, A, D) | Fusion glycoprotein F0 | polymer | 568 | 63218.3 | 3 | UniProt (P03420) Pfam (PF00523) | Human respiratory syncytial virus A (strain A2) | Protein F |
| 4 | J (I) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1883.7 | 1 | In PDB GlyTouCan (G60230HH) | |||
| 5 | K, L (F, A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) |
Sequence modifications
F, A, D: 1 - 513 (UniProt: P03420)
| PDB | External Database | Details |
|---|---|---|
| Ala 102 | Pro 102 | conflict |
| Cys 155 | Ser 155 | engineered mutation |
| Phe 190 | Ser 190 | engineered mutation |
| Leu 207 | Val 207 | engineered mutation |
| Cys 290 | Ser 290 | engineered mutation |
| Val 379 | Ile 379 | conflict |
| Val 447 | Met 447 | conflict |
| Ser 514 | - | expression tag |
| Ala 515 | - | expression tag |
| Ile 516 | - | expression tag |
| Gly 517 | - | expression tag |
| Gly 518 | - | expression tag |
| Tyr 519 | - | expression tag |
| Ile 520 | - | expression tag |
| Pro 521 | - | expression tag |
| Glu 522 | - | expression tag |
| Ala 523 | - | expression tag |
| Pro 524 | - | expression tag |
| Arg 525 | - | expression tag |
| Asp 526 | - | expression tag |
| Gly 527 | - | expression tag |
| Gln 528 | - | expression tag |
| Ala 529 | - | expression tag |
| Tyr 530 | - | expression tag |
| Val 531 | - | expression tag |
| Arg 532 | - | expression tag |
| Lys 533 | - | expression tag |
| Asp 534 | - | expression tag |
| Gly 535 | - | expression tag |
| Glu 536 | - | expression tag |
| Trp 537 | - | expression tag |
| Val 538 | - | expression tag |
| Leu 539 | - | expression tag |
| Leu 540 | - | expression tag |
| Ser 541 | - | expression tag |
| Thr 542 | - | expression tag |
| Phe 543 | - | expression tag |
| Leu 544 | - | expression tag |
| Gly 545 | - | expression tag |
| Gly 546 | - | expression tag |
| Leu 547 | - | expression tag |
| Val 548 | - | expression tag |
| Pro 549 | - | expression tag |
| Arg 550 | - | expression tag |
| Gly 551 | - | expression tag |
| Ser 552 | - | expression tag |
| His 553 | - | expression tag |
| His 554 | - | expression tag |
| His 555 | - | expression tag |
| His 556 | - | expression tag |
| His 557 | - | expression tag |
| His 558 | - | expression tag |
| Ser 559 | - | expression tag |
| Ala 560 | - | expression tag |
| Trp 561 | - | expression tag |
| Ser 562 | - | expression tag |
| His 563 | - | expression tag |
| Pro 564 | - | expression tag |
| Gln 565 | - | expression tag |
| Phe 566 | - | expression tag |
| Glu 567 | - | expression tag |
| Lys 568 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 332103.8 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1883.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 70.9 | |
| All* | Total formula weight | 334058.4 |
