5UC3
Structure of the dominant negative mutant Glucocorticoid Receptor alpha (L733K/N734P) complexed with RU-486
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glucocorticoid receptor | polymer | 257 | 29858.8 | 2 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (Human) | GR,Nuclear receptor subfamily 3 group C member 1 |
| 2 | C, M (A, B) | 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE | non-polymer | 429.6 | 2 | Chemie (486) | |||
| 3 | D, E, N (A, B) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 3 | Chemie (MPD) | |||
| 4 | F, G, H, I, J... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 5 | L (A) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 6 | R, S (A, B) | water | water | 18.0 | 200 | Chemie (HOH) |
Sequence modifications
A, B: 522 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Ser 521 | - | expression tag |
| Lys 733 | Leu 733 | engineered mutation |
| Pro 734 | Asn 734 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 59717.6 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 2010.6 | |
| All* | Total formula weight | 61728.2 |
