5UC3
Structure of the dominant negative mutant Glucocorticoid Receptor alpha (L733K/N734P) complexed with RU-486
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glucocorticoid receptor | polymer | 257 | 29858.8 | 2 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (Human) | GR,Nuclear receptor subfamily 3 group C member 1 |
| 2 | C, M (A, B) | 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE | non-polymer | 429.6 | 2 | Chemie (486) PubChem (55245) PubChem (374394) PubChem (6426861) PubChem (6569219) PubChem (6604870) PubChem (6712024) PubChem (7048587) PubChem (7048709) PubChem (7048710) PubChem (10387949) PubChem (13080184) PubChem (13080185) PubChem (13080187) PubChem (16394559) PubChem (20651195) PubChem (25260940) PubChem (40785059) PubChem (16758830) PubChem (18649237) PubChem (1756360) PubChem (26339468) PubChem (49800048) PubChem (70407138) PubChem (4196) PubChem (6604445) PubChem (124300838) PubChem (124404360) PubChem (9910521) PubChem (11743390) PubChem (73897308) PubChem (124338910) PubChem (130205874) PubChem (131632911) PubChem (133269675) PubChem (133688789) PubChem (138113540) PubChem (139025155) PubChem (145874921) PubChem (170056603) PubChem (170130266) | |||
| 3 | D, E, N (A, B) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 3 | Chemie (MPD) | |||
| 4 | F, G, H, I, J... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 5 | L (A) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) PubChem (23831) | |||
| 6 | R, S (A, B) | water | water | 18.0 | 200 | Chemie (HOH) |
Sequence modifications
A, B: 522 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Ser 521 | - | expression tag |
| Lys 733 | Leu 733 | engineered mutation |
| Pro 734 | Asn 734 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 59717.6 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 2010.6 | |
| All* | Total formula weight | 61728.2 |
