5U6V
X-ray crystal structure of 1,2,3-triazolobenzodiazepine in complex with BRD2(D2)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bromodomain-containing protein 2 | polymer | 110 | 12914.8 | 1 | UniProt (P25440) Pfam (PF00439) | Homo sapiens (Human) | O27.1.1,Really interesting new gene 3 protein |
| 2 | B (A) | 5-[7-(4-chlorophenyl)-1-methyl-6,7-dihydro-5H-[1,2,3]triazolo[1,5-d][1,4]benzodiazepin-9-yl]pyridin-2-amine | non-polymer | 402.9 | 1 | Chemie (7WY) | |||
| 3 | C, D, E, F, G (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 4 | H (A) | water | water | 18.0 | 128 | Chemie (HOH) |
Sequence modifications
A: 347 - 455 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Gly 346 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 12914.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 713.2 | |
| All* | Total formula weight | 13628.0 |
