5U5P
Crystal Structure and X-ray Diffraction Data Collection of Importin-alpha from Mus Musculus Complexed with a MLH1 NLS Peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (C, B) | DNA mismatch repair protein Mlh1 | polymer | 10 | 1299.4 | 2 | UniProt (P40692) | Homo sapiens | MutL protein homolog 1 |
| 2 | C (A) | Importin subunit alpha-1 | polymer | 510 | 55330.6 | 1 | UniProt (P52293) Pfam (PF01749) Pfam (PF00514) Pfam (PF16186) | Mus musculus (Mouse) | Importin alpha P1,Karyopherin subunit alpha-2,Pendulin,Pore targeting complex 58 kDa subunit,PTAC58,RAG cohort protein 1,SRP1-alpha |
| 3 | D (A) | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | non-polymer | 154.3 | 1 | Chemie (DTT) | |||
| 4 | E, F, G (C, B, A) | water | water | 18.0 | 224 | Chemie (HOH) |
Sequence modifications
A: 70 - 529 (UniProt: P52293)
| PDB | External Database | Details |
|---|---|---|
| Met 20 | - | initiating methionine |
| His 21 | - | expression tag |
| His 22 | - | expression tag |
| His 23 | - | expression tag |
| His 24 | - | expression tag |
| His 25 | - | expression tag |
| His 26 | - | expression tag |
| Ser 27 | - | expression tag |
| Ser 28 | - | expression tag |
| Gly 29 | - | expression tag |
| Leu 30 | - | expression tag |
| Val 31 | - | expression tag |
| Pro 32 | - | expression tag |
| Arg 33 | - | expression tag |
| Gly 34 | - | expression tag |
| Ser 35 | - | expression tag |
| Gly 36 | - | expression tag |
| Met 37 | - | expression tag |
| Lys 38 | - | expression tag |
| Glu 39 | - | expression tag |
| Thr 40 | - | expression tag |
| Ala 41 | - | expression tag |
| Ala 42 | - | expression tag |
| Ala 43 | - | expression tag |
| Lys 44 | - | expression tag |
| Phe 45 | - | expression tag |
| Glu 46 | - | expression tag |
| Arg 47 | - | expression tag |
| Gln 48 | - | expression tag |
| His 49 | - | expression tag |
| Met 50 | - | expression tag |
| Asp 51 | - | expression tag |
| Ser 52 | - | expression tag |
| Pro 53 | - | expression tag |
| Asp 54 | - | expression tag |
| Leu 55 | - | expression tag |
| Gly 56 | - | expression tag |
| Thr 57 | - | expression tag |
| Asp 58 | - | expression tag |
| Asp 59 | - | expression tag |
| Asp 60 | - | expression tag |
| Asp 61 | - | expression tag |
| Lys 62 | - | expression tag |
| Ala 63 | - | expression tag |
| Met 64 | - | expression tag |
| Ala 65 | - | expression tag |
| Asp 66 | - | expression tag |
| Ile 67 | - | expression tag |
| Gly 68 | - | expression tag |
| Ser 69 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 57929.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 154.3 | |
| All* | Total formula weight | 58083.7 |
