5U5M
CRYSTAL STRUCTURE OF I83E MEDITOPE-ENABLED TRASTUZUMAB WITH AZIDO-MEDITOPE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MEMAB TRASTUZUMAB, LIGHT CHAIN | polymer | 214 | 23518.0 | 1 | Homo sapiens (HUMAN) | ||
| 2 | B (B) | MEMAB TRASTUZUMAB, HEAVY CHAIN | polymer | 223 | 23774.6 | 1 | Homo sapiens (HUMAN) | ||
| 3 | C (E) | Protein L | polymer | 63 | 6850.6 | 1 | UniProt (Q51918) Pfam (PF02246) | Finegoldia magna (Peptostreptococcus magnus) | |
| 4 | D (C) | Immunoglobulin G binding protein A | polymer | 54 | 6037.5 | 1 | UniProt (Q2UW42) Pfam (PF02216) UniProt (by SIFTS) (P02976) | Staphylococcus aureus | |
| 5 | E (D) | AZIDO-PEG4-MEDITOPE | polymer | 13 | 1838.1 | 1 | synthetic construct | ||
| 6 | F (B) | MESO-ERYTHRITOL | non-polymer | 122.1 | 1 | Chemie (MRY) | |||
| 7 | G, H, I, J, K (A, B, E, C, D) | water | water | 18.0 | 732 | Chemie (HOH) |
Sequence modifications
E: 21 - 81 (UniProt: Q51918)
C: 4 - 54 (UniProt: Q2UW42)
| PDB | External Database | Details |
|---|---|---|
| Ser 19 | - | expression tag |
| Glu 20 | - | expression tag |
| Ile 34 | Thr 490 | engineered mutation |
| Ala 55 | Asp 511 | engineered mutation |
| Asn 73 | Tyr 529 | engineered mutation |
| His 74 | Thr 530 | engineered mutation |
| Met 75 | Ile 531 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ser 2 | - | expression tag |
| Tyr 3 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 62018.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 122.1 | |
| All* | Total formula weight | 62141.0 |
