5U2C
BRD4 second bromodomain (BD2) in complex with dual PI3 kinase (PI3K) inhibitor SF2558HA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bromodomain-containing protein 4 | polymer | 124 | 14202.4 | 2 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (Human) | Protein HUNK1 |
| 2 | C, D (A, B) | N-hydroxy-4-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]benzamide | non-polymer | 372.4 | 2 | Chemie (82Y) |
Sequence modifications
A, B: 342 - 460 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Gly 337 | - | expression tag |
| Gly 338 | - | expression tag |
| Gly 339 | - | expression tag |
| Ile 340 | - | expression tag |
| Leu 341 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28404.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 744.8 | |
| All* | Total formula weight | 29149.7 |
