5U09

High-resolution crystal structure of the human CB1 cannabinoid receptor

Replaces:  5TJV

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Cannabinoid receptor 1,GlgA glycogen synthase	polymer	508	57395.4	1	UniProt (P21554) UniProt (Q9V2J8) Pfam (PF00001) Pfam (PF13692)	Homo sapiens (Human)	CB1,CANN6,Glycogen synthase
2	B, C, D, E, F... (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	9	Chemie (PEG)
3	H, I, J, L (A)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
4	K (A)	N-[(2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)butan-2-yl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide	non-polymer		516.0	1	Chemie (7DY)
5	P (A)	water	water		18.0	62	Chemie (HOH)

Sequence modifications

A: 90 - 301 (UniProt: P21554)

PDB	External Database	Details
Gly 89	-	expression tag
Ala 210	Thr 210	engineered mutation

A: 1001 - 1196 (UniProt: Q9V2J8)
A: 333 - 421 (UniProt: P21554)

PDB	External Database	Details
His 422	-	expression tag
His 423	-	expression tag
His 424	-	expression tag
His 425	-	expression tag
His 426	-	expression tag
His 427	-	expression tag
His 428	-	expression tag
His 429	-	expression tag
His 430	-	expression tag
His 431	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	57395.4
Non-Polymers*	Number of molecules	14
	Total formula weight	1855.3
All*	Total formula weight	59250.7

*Water molecules are not included.