5U09

High-resolution crystal structure of the human CB1 cannabinoid receptor

Replaces:  5TJV

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004949	molecular_function	cannabinoid receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue PEG A 1201

Chain	Residue
A	LEU209
A	VAL228

---

site_id	AC2
Number of Residues	1
Details	binding site for residue PEG A 1202

Chain	Residue
A	HOH1319

---

site_id	AC3
Number of Residues	1
Details	binding site for residue PEG A 1203

Chain	Residue
A	VAL234

---

site_id	AC4
Number of Residues	3
Details	binding site for residue PEG A 1204

Chain	Residue
A	SER1015
A	ARG1016
A	ASP1017

---

site_id	AC5
Number of Residues	2
Details	binding site for residue PEG A 1205

Chain	Residue
A	LEU399
A	ARG405

---

site_id	AC6
Number of Residues	2
Details	binding site for residue PEG A 1206

Chain	Residue
A	TRP241
A	HOH1308

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 A 1207

Chain	Residue
A	LYS402
A	ARG405
A	ARG409

---

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 A 1208

Chain	Residue
A	HIS219
A	ARG220
A	GLY1144
A	ARG1147
A	HOH1311

---

site_id	AC9
Number of Residues	3
Details	binding site for residue SO4 A 1209

Chain	Residue
A	GLU133
A	PRO394
A	ILE395

---

site_id	AD1
Number of Residues	17
Details	binding site for residue 7DY A 1210

Chain	Residue
A	MET103
A	ASP104
A	ILE105
A	ILE119
A	SER123
A	GLY166
A	PHE170
A	LEU193
A	VAL196
A	TRP279
A	PHE379
A	ALA380
A	SER383
A	MET384
A	CYS386
A	LEU387
A	HOH1302

---

site_id	AD2
Number of Residues	2
Details	binding site for residue SO4 A 1211

Chain	Residue
A	ASN187
A	HOH1303

---

site_id	AD3
Number of Residues	1
Details	binding site for residue PEG A 1212

Chain	Residue
A	MET240

---

site_id	AD4
Number of Residues	1
Details	binding site for residue PEG A 1213

Chain	Residue
A	THR125

---

site_id	AD5
Number of Residues	4
Details	binding site for residue PEG A 1214

Chain	Residue
A	LYS1053
A	TYR1120
A	GLY1161
A	PRO1163

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727

Chain	Residue	Details
A	LEU117-LEU142

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727

Chain	Residue	Details
A	HIS143-HIS154
A	ASP213-LYS232

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727

Chain	Residue	Details
A	PHE155-ILE175

---

site_id	SWS_FT_FI4
Number of Residues	39
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727

Chain	Residue	Details
A	ASP176-ASN187
A	ASN256-GLU273
A	ASP366-THR377

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727

Chain	Residue	Details
A	VAL188-ILE212

---

site_id	SWS_FT_FI6
Number of Residues	22
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727

Chain	Residue	Details
A	ALA233-TRP255

---

site_id	SWS_FT_FI7
Number of Residues	25
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727

Chain	Residue	Details
A	THR274-TRP299

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727

Chain	Residue	Details
A	LEU345-TYR365

---

site_id	SWS_FT_FI9
Number of Residues	21
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727

Chain	Residue	Details
A	VAL378-LEU399

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:21895628

Chain	Residue	Details
A	CYS415

---