5TZ2
Crystal structure of human CD47 ECD bound to Fab of C47B222
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | H | C47B222 Fab Heavy Chain | polymer | 229 | 24643.6 | 1 | Homo sapiens | ||
2 | L | C47B222 Fab Light Chain | polymer | 214 | 23406.1 | 1 | Homo sapiens | ||
3 | C | Leukocyte surface antigen CD47 | polymer | 129 | 14764.5 | 1 | UniProt (Q08722) Pfam (PF08204) In PDB | Homo sapiens (Human) | Antigenic surface determinant protein OA3,Integrin-associated protein,IAP,Protein MER6 |
4 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
5 | L | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
6 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
7 | water | water | 18.0 | 105 | Chemie (HOH) |
Sequence modifications
C: 1 - 123 (UniProt: Q08722)
PDB | External Database | Details |
---|---|---|
Gly 15 | Cys 33 | engineered mutation |
His 124 | - | expression tag |
His 125 | - | expression tag |
His 126 | - | expression tag |
His 127 | - | expression tag |
His 128 | - | expression tag |
His 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 62814.2 | |
Branched | Number of molecules | 2 |
Total formula weight | 848.8 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 755.7 | |
All* | Total formula weight | 64418.7 |