5TXS

Crystal structure of an anaplastic lymphoma kinase-derived neuroblastoma tumor antigen bound to the Human Major Histocompatibility Complex Class I molecule HLA-B*1501

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	HLA class I histocompatibility antigen, B-15 alpha chain	polymer	298	34508.1	1	UniProt (P30464) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P01889)	Homo sapiens (Human)	MHC class I antigen B*15
2	B (B)	Beta-2-microglobulin	polymer	100	11879.4	1	UniProt (P61769) Pfam (PF07654)	Homo sapiens (Human)
3	C (C)	anapestic lymphoma kinase-derived neuroblastoma tumor antigen	polymer	9	1087.2	1		Homo sapiens
4	D, E, F (A, B, C)	water	water		18.0	544	Chemie (HOH)

Sequence modifications

A: 1 - 280 (UniProt: P30464)

PDB	External Database	Details
Met 0	-	initiating methionine
Gly 281	-	expression tag
Ser 282	-	expression tag
Leu 283	-	expression tag
His 284	-	expression tag
His 285	-	expression tag
Ile 286	-	expression tag
Leu 287	-	expression tag
Asp 288	-	expression tag
Ala 289	-	expression tag
Gln 290	-	expression tag
Lys 291	-	expression tag
Met 292	-	expression tag
Val 293	-	expression tag
Trp 294	-	expression tag
Asn 295	-	expression tag
His 296	-	expression tag
Arg 297	-	expression tag

B: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
Met 0	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	47474.6
All*	Total formula weight	47474.6

*Water molecules are not included.