5TX5

Rip1 Kinase ( flag 1-294, C34A, C127A, C233A, C240A) with GSK772

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Receptor-interacting serine/threonine-protein kinase 1	polymer	303	34596.9	2	UniProt (Q13546) Pfam (PF07714)	Homo sapiens (Human)	Cell death protein RIP,Receptor-interacting protein 1,RIP-1,Serine/threonine-protein kinase RIP
2	C, D (A, B)	3-benzyl-N-[(3S)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-1H-1,2,4-triazole-5-carboxamide	non-polymer		377.4	2	Chemie (7MJ)
3	E, F (A, B)	water	water		18.0	34	Chemie (HOH)

Sequence modifications

A, B: 1 - 294 (UniProt: Q13546)

PDB	External Database	Details
Met -8	-	initiating methionine
Asp -7	-	expression tag
Tyr -6	-	expression tag
Lys -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Lys 0	-	expression tag
Ala 34	Cys 34	engineered mutation
Ala 127	Cys 127	engineered mutation
Ala 233	Cys 233	engineered mutation
Ala 240	Cys 240	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	69193.8
Non-Polymers*	Number of molecules	2
	Total formula weight	754.8
All*	Total formula weight	69948.6

*Water molecules are not included.