5TWM
CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 L30S NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NS5B RNA-dependent RNA POLYMERASE | polymer | 574 | 63931.4 | 1 | UniProt (Q99IB8) Pfam (PF00998) | Hepatitis C virus genotype 2a (isolate JFH-1) (HCV) | |
| 2 | B (A) | 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide | non-polymer | 488.6 | 1 | Chemie (7NG) | |||
| 3 | C, D, E, F (A) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | G (A) | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL | non-polymer | 398.5 | 1 | Chemie (PE5) | |||
| 5 | H, I (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 2 | Chemie (PG4) | |||
| 6 | J (A) | water | water | 18.0 | 383 | Chemie (HOH) |
Sequence modifications
A: 1 - 573 (UniProt: Q99IB8)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ser 30 | Leu 2472 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 63931.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1659.7 | |
| All* | Total formula weight | 65591.2 |
