5TVN
Crystal structure of the LSD-bound 5-HT2B receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Chimera protein of human 5-hydroxytryptamine receptor 2B and E. Coli soluble cytochrome b562 | polymer | 402 | 45233.0 | 1 | UniProt (P41595) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) | Homo sapiens (Human) | 5-HT2B,Serotonin receptor 2B,Cytochrome b-562,5-HT2B,Serotonin receptor 2B |
| 2 | B (A) | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide | non-polymer | 323.4 | 1 | Chemie (7LD) | |||
| 3 | C (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 4 | D (A) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 1 | Chemie (OLC) | |||
| 5 | E (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 6 | F (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 7 | G (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 41 - 248 (UniProt: P41595)
A: 1001 - 1106 (UniProt: P0ABE7)
A: 313 - 400 (UniProt: P41595)
| PDB | External Database | Details |
|---|---|---|
| Trp 144 | Met 144 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Trp 1007 | Met 29 | engineered mutation |
| Ile 1102 | His 124 | engineered mutation |
| Leu 1106 | Arg 128 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45233.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1267.7 | |
| All* | Total formula weight | 46500.7 |
