5TSR

Crystal structure of PRL-3 phosphatase in complex with the Bateman domain of CNNM3 magnesium transporter

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Protein tyrosine phosphatase type IVA 3	polymer	172	19380.5	2	UniProt (O75365) Pfam (PF22785)	Homo sapiens (Human)	PRL-R,Protein-tyrosine phosphatase 4a3,Protein-tyrosine phosphatase of regenerating liver 3,PRL-3
2	B, D (B, D)	Metal transporter CNNM3	polymer	155	17634.0	2	UniProt (Q8NE01) Pfam (PF00571)	Homo sapiens (Human)	Ancient conserved domain-containing protein 3,Cyclin-M3
3	E, F, G (A, C, D)	water	water		18.0	3	Chemie (HOH)

Sequence modifications

A, C: 1 - 169 (UniProt: O75365)

PDB	External Database	Details
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Ala 104	Cys 104	engineered mutation

B, D: 309 - 452 (UniProt: Q8NE01)

PDB	External Database	Details
Gly 298	-	expression tag
Pro 299	-	expression tag
Leu 300	-	expression tag
Asn 301	-	expression tag
Met 302	-	expression tag
Ile 303	-	expression tag
Gln 304	-	expression tag
Gly 305	-	expression tag
Val 306	-	expression tag
Leu 307	-	expression tag
Glu 308	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	74029.0
All*	Total formula weight	74029.0

*Water molecules are not included.