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5TSR

Crystal structure of PRL-3 phosphatase in complex with the Bateman domain of CNNM3 magnesium transporter

Functional Information from GO Data
ChainGOidnamespacecontents
A0004721molecular_functionphosphoprotein phosphatase activity
A0004725molecular_functionprotein tyrosine phosphatase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005886cellular_componentplasma membrane
A0006355biological_processregulation of DNA-templated transcription
A0006470biological_processprotein dephosphorylation
A0007219biological_processNotch signaling pathway
A0009966biological_processregulation of signal transduction
A0016020cellular_componentmembrane
A0016311biological_processdephosphorylation
A0016787molecular_functionhydrolase activity
A0043117biological_processpositive regulation of vascular permeability
A0043542biological_processendothelial cell migration
A1900746biological_processregulation of vascular endothelial growth factor signaling pathway
A1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
A1904951biological_processpositive regulation of establishment of protein localization
A1990830biological_processcellular response to leukemia inhibitory factor
B0010960biological_processmagnesium ion homeostasis
C0004721molecular_functionphosphoprotein phosphatase activity
C0004725molecular_functionprotein tyrosine phosphatase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005769cellular_componentearly endosome
C0005886cellular_componentplasma membrane
C0006355biological_processregulation of DNA-templated transcription
C0006470biological_processprotein dephosphorylation
C0007219biological_processNotch signaling pathway
C0009966biological_processregulation of signal transduction
C0016020cellular_componentmembrane
C0016311biological_processdephosphorylation
C0016787molecular_functionhydrolase activity
C0043117biological_processpositive regulation of vascular permeability
C0043542biological_processendothelial cell migration
C1900746biological_processregulation of vascular endothelial growth factor signaling pathway
C1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
C1904951biological_processpositive regulation of establishment of protein localization
C1990830biological_processcellular response to leukemia inhibitory factor
D0010960biological_processmagnesium ion homeostasis
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000305
ChainResidueDetails
AASP72
CASP72

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160
ChainResidueDetails
AALA104
CALA104

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING:
ChainResidueDetails
AARG110
CARG110

237735

PDB entries from 2025-06-18

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