5TQR
ctPRC2 in an autoinhibited conformation bound to S-adenosylmethionine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Polycomb Protein EED | polymer | 605 | 66021.4 | 1 | UniProt (G0S8H7) Pfam (PF00400) Pfam (PF22038) | Chaetomium thermophilum | |
| 2 | B (B) | Histone-lysine N-methyltransferase EZH2, Polycomb protein SUZ12 | polymer | 937 | 106869.6 | 1 | UniProt (G0SDW4) UniProt (G0RYC6) Pfam (PF18601) Pfam (PF18600) Pfam (PF21509) Pfam (PF00856) Pfam (PF09733) | Chaetomium thermophilum | |
| 3 | C, D, E, F, G... (B) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 4 | K (B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) PubChem (5136) PubChem (34755) PubChem (58633578) PubChem (60038769) PubChem (73897310) PubChem (58766358) PubChem (87224684) PubChem (131697735) PubChem (9865603) PubChem (145712080) PubChem (12312798) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094) | |||
| 5 | L, M (A, B) | water | water | 18.0 | 244 | Chemie (HOH) |
Sequence modifications
A: 1 - 565 (UniProt: G0S8H7)
B: 191 - 950 (UniProt: G0SDW4)
B: 2530 - 2691 (UniProt: G0RYC6)
| PDB | External Database | Details |
|---|---|---|
| Met -39 | - | expression tag |
| Ala -38 | - | expression tag |
| Ser -37 | - | expression tag |
| Ala -36 | - | expression tag |
| Trp -35 | - | expression tag |
| Ser -34 | - | expression tag |
| His -33 | - | expression tag |
| Pro -32 | - | expression tag |
| Gln -31 | - | expression tag |
| Phe -30 | - | expression tag |
| Glu -29 | - | expression tag |
| Lys -28 | - | expression tag |
| Gly -27 | - | expression tag |
| Gly -26 | - | expression tag |
| Gly -25 | - | expression tag |
| Ser -24 | - | expression tag |
| Gly -23 | - | expression tag |
| Gly -22 | - | expression tag |
| Gly -21 | - | expression tag |
| Ser -20 | - | expression tag |
| Gly -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ala -16 | - | expression tag |
| Trp -15 | - | expression tag |
| Ser -14 | - | expression tag |
| His -13 | - | expression tag |
| Pro -12 | - | expression tag |
| Gln -11 | - | expression tag |
| Phe -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Lys -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 182 | - | expression tag |
| Asn 183 | - | expression tag |
| His 184 | - | expression tag |
| His 185 | - | expression tag |
| His 186 | - | expression tag |
| His 187 | - | expression tag |
| His 188 | - | expression tag |
| His 189 | - | expression tag |
| Ala 190 | - | expression tag |
| Leu 2524 | - | linker |
| Val 2525 | - | linker |
| Pro 2526 | - | linker |
| Arg 2527 | - | linker |
| Gly 2528 | - | linker |
| Ser 2529 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 172891.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 921.7 | |
| All* | Total formula weight | 173812.7 |
