5TQR

ctPRC2 in an autoinhibited conformation bound to S-adenosylmethionine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0006325	biological_process	chromatin organization
B	0006338	biological_process	chromatin remodeling
B	0042054	molecular_function	histone methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN B 8001

Chain	Residue
B	CYS727
B	CYS748
B	CYS755
B	CYS760

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN B 8002

Chain	Residue
B	CYS736
B	CYS755
B	CYS763
B	CYS784

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN B 8003

Chain	Residue
B	CYS729
B	CYS736
B	CYS746
B	CYS727

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN B 8004

Chain	Residue
B	CYS685
B	HIS687
B	CYS691
B	CYS697

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN B 8005

Chain	Residue
B	CYS691
B	CYS709
B	CYS715
B	CYS720

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN B 8006

Chain	Residue
B	CYS685
B	CYS699
B	CYS709
B	CYS713

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN B 8007

Chain	Residue
B	CYS508
B	CYS511
B	CYS516
B	HIS518

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN B 8008

Chain	Residue
B	CYS570
B	CYS574
B	CYS615
B	CYS625

---

site_id	AC9
Number of Residues	12
Details	binding site for residue SAM B 8009

Chain	Residue
B	LEU804
B	CYS807
B	GLY808
B	TYR809
B	LYS852
B	VAL853
B	SER854
B	TYR855
B	ARG877
B	ASN880
B	HIS881
B	TYR918

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	44
Details	Repeat: {"description":"WD 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	Repeat: {"description":"WD 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	39
Details	Repeat: {"description":"WD 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	38
Details	Repeat: {"description":"WD 4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	40
Details	Repeat: {"description":"WD 5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	65
Details	Region: {"description":"Polycomb protein VEFS-Box","evidences":[{"source":"PubMed","id":"26472914","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	122
Details	Domain: {"description":"CXC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00970","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26472914","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	29
Details	Region: {"description":"EBD domain","evidences":[{"source":"PubMed","id":"26472914","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	19
Details	Region: {"description":"SAL domain","evidences":[{"source":"PubMed","id":"26472914","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	20
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	11
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	23
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26472914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28607149","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29904056","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BJS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KJI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KKL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5M5G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WF7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WFD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26472914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28607149","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29904056","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BJS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KJI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5M5G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WF7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WFD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26472914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28607149","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29904056","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BJS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KJI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KKL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5M5G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WF7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WFC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26472914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28607149","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5KKL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TQR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26472914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28607149","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TQR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26472914","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5KKL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26472914","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5KJH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KJI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5M5G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---