5TO8
Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Protein-tyrosine kinase 2-beta | polymer | 282 | 32579.8 | 1 | UniProt (Q14289) Pfam (PF07714) In PDB | Homo sapiens (Human) | Calcium-dependent tyrosine kinase,CADTK,Calcium-regulated non-receptor proline-rich tyrosine kinase,Cell adhesion kinase beta,CAKB,Focal adhesion kinase 2,FADK 2,Proline-rich tyrosine kinase 2,Related adhesion focal tyrosine kinase,RAFTK |
| 2 | A | 25-(methylsulfonyl)-8-(trifluoromethyl)-5,17,18,21,22,23,24,25-octahydro-12H-7,11-(azeno)-16,13-(metheno)pyrido[3,2-i]pyrrolo[1,2-q][1,3,7,11,17]pentaazacyclohenicosin-20(6H)-one | non-polymer | 561.6 | 1 | Chemie (7FM) | |||
| 3 | water | water | 18.0 | 83 | Chemie (HOH) |
Sequence modifications
A: 414 - 692 (UniProt: Q14289)
| PDB | External Database | Details |
|---|---|---|
| Gly 411 | - | expression tag |
| Ser 412 | - | expression tag |
| Met 413 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32579.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 561.6 | |
| All* | Total formula weight | 33141.3 |
