5TL7
Crystal structure of SARS-CoV papain-like protease in complex with C-terminal domain mouse ISG15
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Ubiquitin-like protein ISG15 | polymer | 79 | 9280.7 | 2 | UniProt (Q64339) Pfam (PF00240) | Mus musculus (Mouse) | Interferon-induced 15 kDa protein,Interferon-induced 17 kDa protein,IP17,Ubiquitin cross-reactive protein |
| 2 | B, D (B, D) | Replicase polyprotein 1ab | polymer | 319 | 35809.6 | 2 | UniProt (P0C6X7) Pfam (PF08715) | SARS coronavirus (SARS-CoV) | pp1ab,ORF1ab polyprotein |
| 3 | E, F (B, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 122 | Chemie (HOH) |
Sequence modifications
A, C: 78 - 155 (UniProt: Q64339)
B, D: 2 - 316 (UniProt: P0C6X7)
| PDB | External Database | Details |
|---|---|---|
| Met 77 | - | initiating methionine |
| Aye 155 | Gly 155 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -2 | - | initiating methionine |
| Ala -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Met 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 90180.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 130.8 | |
| All* | Total formula weight | 90311.5 |
