5TL7

Crystal structure of SARS-CoV papain-like protease in complex with C-terminal domain mouse ISG15

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity
D	0006508	biological_process	proteolysis
D	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN B 401

Chain	Residue
B	CYS190
B	CYS193
B	CYS225
B	CYS227

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN D 401

Chain	Residue
D	CYS190
D	CYS193
D	CYS225
D	CYS227

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site_id	AC3
Number of Residues	8
Details	binding site for Di-peptide GLY C 154 and AYE C 155

Chain	Residue
D	TRP107
D	ASN110
D	CYS112
D	TYR113
D	LEU163
D	GLY164
D	GLY272
C	ARG153

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site_id	AC4
Number of Residues	31
Details	binding site for Di-peptide AYE C 155 and CYS D 112

Chain	Residue
B	VAL49
B	ASN50
C	ASN92
C	ILE93
C	LYS108
C	VAL109
C	SER110
C	GLN111
C	GLU113
C	GLN114
C	GLY154
D	TYR73
D	TRP107
D	ASN110
D	ASN111
D	TYR113
D	LEU114
D	SER115
D	SER116
D	LEU151
D	ILE152
D	LEU153
D	ALA154
D	SER156
D	ASN157
D	LEU163
D	HIS172
D	HIS176
D	GLY272
D	TYR274
D	HOH504

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	74
Details	ZN_FING: C4-type => ECO:0000255|PROSITE-ProRule:PRU00444, ECO:0000269|PubMed:16306590

Chain	Residue	Details
B	CYS190-CYS227
D	CYS190-CYS227

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site_id	SWS_FT_FI2
Number of Residues	6
Details	ACT_SITE: For PL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00444, ECO:0000269|PubMed:16306590

Chain	Residue	Details
D	HIS273
D	ASP287
B	CYS112
B	HIS273
B	ASP287
D	CYS112

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site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00444

Chain	Residue	Details
B	CYS227
D	CYS190
D	CYS193
D	CYS225
D	CYS227
B	CYS225
B	CYS193
B	CYS190

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 830

Chain

Residue

Details

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site_id	MCSA2
Number of Residues
Details	M-CSA 830

Chain

Residue

Details

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