5THR
Cryo-EM structure of a BG505 Env-sCD4-17b-8ANC195 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | BG505 SOSIP gp41 | polymer | 153 | 17146.5 | 3 | UniProt (Q2N0S6) Pfam (PF00517) | Human immunodeficiency virus 1 | |
| 2 | D, E, F (D, E, F) | BG505 SOSIP gp120 | polymer | 481 | 54064.3 | 3 | UniProt (Q2N0S6) Pfam (PF00516) | Human immunodeficiency virus 1 | |
| 3 | G, H, I (G, H, I) | T-cell surface glycoprotein CD4 | polymer | 192 | 21472.3 | 3 | UniProt (P01730) Pfam (PF00047) Pfam (PF05790) | Homo sapiens (Human) | T-cell surface antigen T4/Leu-3 |
| 4 | J, K, L (J, K, L) | 17b Fab VL domain | polymer | 214 | 23399.9 | 3 | Homo sapiens (Human) | ||
| 5 | M, N, O (M, N, O) | 17b Fab VH domain | polymer | 229 | 24457.4 | 3 | Homo sapiens (Human) | ||
| 6 | P, R, T (P, R, T) | 8ANC195 G52K5 VH domain | polymer | 244 | 26125.3 | 3 | Homo sapiens (Human) | ||
| 7 | Q, S, U (Q, S, U) | 8ANC195 G52K5 VL domain | polymer | 215 | 23402.0 | 3 | Homo sapiens (Human) | ||
| 8 | BA, V, Y (b, V, Y) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
| 9 | AA, CA, DA, W, X... (a, c, d, W, X...) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 6 | In PDB GlyTouCan (G22768VO) |
Sequence modifications
A, B, C: 512 - 664 (UniProt: Q2N0S6)
D, E, F: 31 - 508 (UniProt: Q2N0S6)
G, H, I: 1 - 182 (UniProt: P01730)
| PDB | External Database | Details |
|---|---|---|
| Pro 559 | Ile 556 | conflict |
| Cys 605 | Thr 602 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asn 332 | Thr 330 | conflict |
| Cys 501 | Ala 498 | conflict |
| Arg 509 | - | expression tag |
| Arg 510 | - | expression tag |
| Arg 511 | - | expression tag |
| Arg 512 | - | expression tag |
| Arg 513 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ile 183 | - | expression tag |
| Asp 184 | - | expression tag |
| Gly 185 | - | expression tag |
| Arg 186 | - | expression tag |
| His 187 | - | expression tag |
| His 188 | - | expression tag |
| His 189 | - | expression tag |
| His 190 | - | expression tag |
| His 191 | - | expression tag |
| His 192 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 21 |
| Total formula weight | 570202.9 | |
| Branched | Number of molecules | 9 |
| Total formula weight | 7711.0 | |
| All* | Total formula weight | 577913.9 |
