5THR
Cryo-EM structure of a BG505 Env-sCD4-17b-8ANC195 complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | BG505 SOSIP gp41 | polymer | 153 | 17146.5 | 3 | UniProt (Q2N0S6) Pfam (PF00517) In PDB | Human immunodeficiency virus 1 | |
2 | D, E, F | BG505 SOSIP gp120 | polymer | 481 | 54064.3 | 3 | UniProt (Q2N0S6) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | |
3 | G, H, I | T-cell surface glycoprotein CD4 | polymer | 192 | 21472.3 | 3 | UniProt (P01730) Pfam (PF00047) Pfam (PF05790) In PDB | Homo sapiens (Human) | T-cell surface antigen T4/Leu-3 |
4 | J, K, L | 17b Fab VL domain | polymer | 214 | 23399.9 | 3 | Homo sapiens (Human) | ||
5 | M, N, O | 17b Fab VH domain | polymer | 229 | 24457.4 | 3 | Homo sapiens (Human) | ||
6 | P, R, T | 8ANC195 G52K5 VH domain | polymer | 244 | 26125.3 | 3 | Homo sapiens (Human) | ||
7 | Q, S, U | 8ANC195 G52K5 VL domain | polymer | 215 | 23402.0 | 3 | Homo sapiens (Human) | ||
8 | b, V, Y | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
9 | a, c, d, W, X... | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 6 | In PDB GlyTouCan (G22768VO) |
Sequence modifications
A, B, C: 512 - 664 (UniProt: Q2N0S6)
D, E, F: 31 - 508 (UniProt: Q2N0S6)
G, H, I: 1 - 182 (UniProt: P01730)
PDB | External Database | Details |
---|---|---|
Pro 559 | Ile 556 | conflict |
Cys 605 | Thr 602 | conflict |
PDB | External Database | Details |
---|---|---|
Asn 332 | Thr 330 | conflict |
Cys 501 | Ala 498 | conflict |
Arg 509 | - | expression tag |
Arg 510 | - | expression tag |
Arg 511 | - | expression tag |
Arg 512 | - | expression tag |
Arg 513 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ile 183 | - | expression tag |
Asp 184 | - | expression tag |
Gly 185 | - | expression tag |
Arg 186 | - | expression tag |
His 187 | - | expression tag |
His 188 | - | expression tag |
His 189 | - | expression tag |
His 190 | - | expression tag |
His 191 | - | expression tag |
His 192 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 21 |
Total formula weight | 570202.9 | |
Branched | Number of molecules | 9 |
Total formula weight | 7711.0 | |
All* | Total formula weight | 577913.9 |