5THI
Crystal Structure of 2-hydroxycyclohepta-2,4,6-trien-1-one bound to human carbonic anhydrase 2 L198G
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Carbonic anhydrase 2 | polymer | 260 | 29233.0 | 1 | UniProt (P00918) Pfam (PF00194) In PDB | Homo sapiens (Human) | Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II |
| 2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | A | 2-HYDROXYCYCLOHEPTA-2,4,6-TRIEN-1-ONE | non-polymer | 122.1 | 1 | Chemie (0TR) | |||
| 4 | A | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 5 | A | MERCURIBENZOIC ACID | non-polymer | 321.7 | 1 | Chemie (MBO) | |||
| 6 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 7 | water | water | 18.0 | 207 | Chemie (HOH) |
Sequence modifications
A: 1 - 261 (UniProt: P00918)
| PDB | External Database | Details |
|---|---|---|
| Gly 198 | Leu 197 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29233.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 885.5 | |
| All* | Total formula weight | 30118.5 |
