5THG
Engineered variant of I-OnuI meganuclease targeting the HIV CCR5 gene; harbors 43 point mutations relative to wild-type I-OnuI
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | I-OnuI_e-hCCR5 | polymer | 304 | 35144.6 | 2 | synthetic construct | ||
| 2 | B, E (B, E) | DNA (29-MER) | polymer | 29 | 8781.6 | 2 | synthetic construct | ||
| 3 | C, F (C, F) | DNA (29-MER) | polymer | 29 | 9048.8 | 2 | synthetic construct | ||
| 4 | G, H, J, K (A, D) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 5 | I, L (B, E) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 105950.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 344.5 | |
| All* | Total formula weight | 106294.7 |
