5THC
Crystal structure of H10 hemagglutinin mutant (T193D-Q226L-G228S) from Jiangxi-Donghu (2013) H10N8 influenza virus in complex with 6'-SLNLN
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E | Hemagglutinin HA1 chain | polymer | 323 | 35284.9 | 3 | UniProt (A0A0J9X252) Pfam (PF00509) UniProt (by SIFTS) (A0A059T4A1) In PDB | Influenza A virus | |
| 2 | B, D, F | Hemagglutinin HA2 chain | polymer | 180 | 20698.8 | 3 | UniProt (A0A0J9X253) Pfam (PF00509) UniProt (by SIFTS) (A0A059T4A1) In PDB | Influenza A virus | |
| 3 | G | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | H | N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 674.6 | 1 | In PDB BIRD (PRD_900046) GlyTouCan (G73578JC) | 6'-sialyl-N-acetyllactosamine | ||
| 5 | I | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 6 | A, C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 7 | C | N-acetyl-alpha-neuraminic acid | non-polymer | 309.3 | 1 | Chemie (SIA) | |||
| 8 | water | water | 18.0 | 168 | Chemie (HOH) |
Sequence modifications
A, C, E: 7 - 326 (UniProt: A0A0J9X252)
B, D, F: 2 - 174 (UniProt: A0A0J9X253)
| PDB | External Database | Details |
|---|---|---|
| Thr 193 | Asp 190 | engineered mutation |
| Leu 226 | Gln 223 | engineered mutation |
| Ser 228 | Gly 225 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 175 | - | expression tag |
| Gly 176 | - | expression tag |
| Arg 177 | - | expression tag |
| Leu 178 | - | expression tag |
| Val 179 | - | expression tag |
| Pro 180 | - | expression tag |
| Arg 181 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 167950.9 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1847.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 972.9 | |
| All* | Total formula weight | 170771.4 |
