5TH6

Structure determination of a potent, selective antibody inhibitor of human MMP9 (apo MMP9)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Matrix metalloproteinase-9,Matrix metalloproteinase-9	polymer	231	25962.1	4	UniProt (P14780) Pfam (PF00413)	Homo sapiens (Human)	MMP-9,92 kDa gelatinase,92 kDa type IV collagenase,Gelatinase B,GELB,MMP-9,92 kDa gelatinase,92 kDa type IV collagenase,Gelatinase B,GELB
2	E, F, J, K, O... (A, B, C, D)	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
3	G, H, I, L, M... (A, B, C, D)	CALCIUM ION	non-polymer		40.1	12	Chemie (CA)
4	AA, BA, Y, Z (C, D, A, B)	water	water		18.0	921	Chemie (HOH)

Sequence modifications

A, B, C, D: 40 - 215 (UniProt: P14780)

PDB	External Database	Details
Met 38	-	initiating methionine
Ala 39	-	expression tag

A, B, C, D: 391 - 443 (UniProt: P14780)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	103848.4
Non-Polymers*	Number of molecules	20
	Total formula weight	1004.2
All*	Total formula weight	104852.7

*Water molecules are not included.