5TFG

Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with 5-methyl-UTP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cystic fibrosis transmembrane conductance regulator	polymer	229	25525.4	1	UniProt (P13569) Pfam (PF00005) In PDB	Homo sapiens (Human)	CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel
2	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
3	A	5-Methyluridine triphosphate	non-polymer		498.2	1	Chemie (M5T)
4		water	water		18.0	190	Chemie (HOH)

Sequence modifications

A: 387 - 646 (UniProt: P13569)

PDB	External Database	Details
Ser 386	-	expression tag
-	Phe 405	deletion
-	Gly 406	deletion
-	Glu 407	deletion
-	Leu 408	deletion
-	Phe 409	deletion
-	Glu 410	deletion
-	Lys 411	deletion
-	Ala 412	deletion
-	Lys 413	deletion
-	Gln 414	deletion
-	Asn 415	deletion
-	Asn 416	deletion
-	Asn 417	deletion
-	Asn 418	deletion
-	Arg 419	deletion
-	Lys 420	deletion
-	Thr 421	deletion
-	Ser 422	deletion
-	Asn 423	deletion
-	Gly 424	deletion
-	Asp 425	deletion
-	Asp 426	deletion
-	Ser 427	deletion
-	Leu 428	deletion
-	Phe 429	deletion
-	Phe 430	deletion
-	Ser 431	deletion
-	Asn 432	deletion
-	Phe 433	deletion
-	Ser 434	deletion
-	Leu 435	deletion
-	Leu 436	deletion
Met 470	Val 470	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	25525.4
Non-Polymers*	Number of molecules	2
	Total formula weight	522.5
All*	Total formula weight	26047.9

*Water molecules are not included.